Basic Searches
Searches without any special characters (listed below) will return items that contain the exact value(s) entered in the search field. This means that searching for "ASPIRIN CALCIUM" won't return any items that have "ASPIRIN GLYCINE CALCIUM" because the search term doesn't match exactly.
Boolean Operators
OR - searches with terms separated by " OR " will return items that contain any of the terms in the search.
Example: "ASPIRIN" OR "CALCIUM" will return items that have strings like "ASPIRIN GLYCINE" and "GLYCINE CALCIUM" because they contain at least one of the terms in the search.

AND - searches with terms separated by " AND " will return items that contain all the terms in the search.
Example: "ASPIRIN" AND "CALCIUM" won't return items that have strings "ASPIRIN GLYCINE" and "GLYCINE CALCIUM" because neither contain both terms, but it will return "ASPIRIN GLYCINE CALCIUM" because it contains both search terms.
version 2.5
Substance Class Chemical
Record UNII
S65743JHBS
Record Status Validated (UNII)
Record Version
Show Definitional References Hide Definitional References
Download

Details

Stereochemistry ACHIRAL
Molecular Formula C22H24ClFN4O3
Molecular Weight 446.902
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0
Created by admin on Thu Mar 26 01:21:06 EDT 2020
Edited by admin on Thu Mar 26 01:21:06 EDT 2020
Structure of GEFITINIB

Systematic Names:

  • None recorded
  • {{name}}

SMILES

COC1=C(OCCCN2CCOCC2)C=C3C(NC4=CC(Cl)=C(F)C=C4)=NC=NC3=C1

InChI

XGALLCVXEZPNRQ-UHFFFAOYSA-N
InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
Name Type Language Details References
GEFITINIB
Domain Jurisdiction Naming Organization
drug  
USAN   INN  
EMA EPAR   INN   JAN   MART.   MI   ORANGE BOOK   USAN   VANDF   WHO-DD  
Official Name
English  
GEFITINIB [INN]
Common Name
English  
GEFITINIB [USAN]
Common Name
English  
4-QUINAZOLINAMINE, N-(3-CHLORO-4-FLUOROPHENYL)-7-METHOXY-6-(3-4-MORPHOLIN)PROPOXY)-
Common Name
English  
GEFITINIB [EMA EPAR]
Common Name
English  
ZD-1839
Code
English  
GEFITINIB [VANDF]
Common Name
English  
IRESSA
Brand Name
English  
GEFITINIB [JAN]
Common Name
English  
GEFITINIB [ORANGE BOOK]
Common Name
English  
GEFITINIB [MART.]
Common Name
English  
GEFITINIB [WHO-DD]
Common Name
English  
GEFITINIB [MI]
Common Name
English  
ZD1839
Code
English  
Classification Tree Code System Code References
EU-Orphan Drug EU/3/18/2075
Created by admin on Thu Mar 26 01:21:06 EDT 2020 , Edited by admin on Thu Mar 26 01:21:06 EDT 2020
WHO-ATC L01XE02
Created by admin on Thu Mar 26 01:21:06 EDT 2020 , Edited by admin on Thu Mar 26 01:21:06 EDT 2020
NCI_THESAURUS C129825
Created by admin on Thu Mar 26 01:21:06 EDT 2020 , Edited by admin on Thu Mar 26 01:21:06 EDT 2020
WHO-VATC QL01XE02
Created by admin on Thu Mar 26 01:21:06 EDT 2020 , Edited by admin on Thu Mar 26 01:21:06 EDT 2020
EMA ASSESSMENT REPORTS IRESSA (AUTHORIZED: CARCINOMA, NON-SMALL-CELL LUNG)
Created by admin on Thu Mar 26 01:21:06 EDT 2020 , Edited by admin on Thu Mar 26 01:21:06 EDT 2020
NDF-RT N0000175605
Created by admin on Thu Mar 26 01:21:06 EDT 2020 , Edited by admin on Thu Mar 26 01:21:06 EDT 2020
NDF-RT N0000175076
Created by admin on Thu Mar 26 01:21:06 EDT 2020 , Edited by admin on Thu Mar 26 01:21:06 EDT 2020
NCI_THESAURUS C1967
Created by admin on Thu Mar 26 01:21:06 EDT 2020 , Edited by admin on Thu Mar 26 01:21:06 EDT 2020
FDA ORPHAN DRUG 443014
Created by admin on Thu Mar 26 01:21:06 EDT 2020 , Edited by admin on Thu Mar 26 01:21:06 EDT 2020
LIVERTOX 450
Created by admin on Thu Mar 26 01:21:06 EDT 2020 , Edited by admin on Thu Mar 26 01:21:06 EDT 2020
Code System Code Type Description References
WIKIPEDIA
GEFITINIB
Created by admin on Thu Mar 26 01:21:06 EDT 2020 , Edited by admin on Thu Mar 26 01:21:06 EDT 2020
PRIMARY
ChEMBL
CHEMBL939
Created by admin on Thu Mar 26 01:21:06 EDT 2020 , Edited by admin on Thu Mar 26 01:21:06 EDT 2020
PRIMARY
EVMPD
SUB20637
Created by admin on Thu Mar 26 01:21:06 EDT 2020 , Edited by admin on Thu Mar 26 01:21:06 EDT 2020
PRIMARY
DRUG BANK
DB00317
Created by admin on Thu Mar 26 01:21:06 EDT 2020 , Edited by admin on Thu Mar 26 01:21:06 EDT 2020
PRIMARY
EPA CompTox
184475-35-2
Created by admin on Thu Mar 26 01:21:06 EDT 2020 , Edited by admin on Thu Mar 26 01:21:06 EDT 2020
PRIMARY
NCI_THESAURUS
C1855
Created by admin on Thu Mar 26 01:21:06 EDT 2020 , Edited by admin on Thu Mar 26 01:21:06 EDT 2020
PRIMARY
MERCK INDEX
M5682
Created by admin on Thu Mar 26 01:21:06 EDT 2020 , Edited by admin on Thu Mar 26 01:21:06 EDT 2020
PRIMARY Merck Index
MESH
C419708
Created by admin on Thu Mar 26 01:21:06 EDT 2020 , Edited by admin on Thu Mar 26 01:21:06 EDT 2020
PRIMARY
INN
8204
Created by admin on Thu Mar 26 01:21:06 EDT 2020 , Edited by admin on Thu Mar 26 01:21:06 EDT 2020
PRIMARY
RXCUI
328134
Created by admin on Thu Mar 26 01:21:06 EDT 2020 , Edited by admin on Thu Mar 26 01:21:06 EDT 2020
PRIMARY RxNorm
IUPHAR
4941
Created by admin on Thu Mar 26 01:21:06 EDT 2020 , Edited by admin on Thu Mar 26 01:21:06 EDT 2020
PRIMARY
LactMed
184475-35-2
Created by admin on Thu Mar 26 01:21:06 EDT 2020 , Edited by admin on Thu Mar 26 01:21:06 EDT 2020
PRIMARY
CAS
184475-35-2
Created by admin on Thu Mar 26 01:21:06 EDT 2020 , Edited by admin on Thu Mar 26 01:21:06 EDT 2020
PRIMARY
PUBCHEM
123631
Created by admin on Thu Mar 26 01:21:06 EDT 2020 , Edited by admin on Thu Mar 26 01:21:06 EDT 2020
PRIMARY
Related Record Type Details References
TRANSPORTER -> INHIBITOR
none
Mediator Substance Details
none
Created by admin on Thu Mar 26 01:51:20 EDT 2020 , Edited by admin on Thu Mar 26 01:51:20 EDT 2020
TRANSPORTER -> SUBSTRATE
none
Mediator Substance Details
none
Created by admin on Thu Mar 26 01:21:12 EDT 2020 , Edited by admin on Thu Mar 26 01:21:12 EDT 2020
BINDER->LIGAND
Mediator Substance Details
none
BINDING
In vitro binding of gefitinib to human plasma proteins (serum albumin and ?1-acid glycoprotein) is 90% and is independent of drug concentrations.
Created by admin on Thu Mar 26 01:21:08 EDT 2020 , Edited by admin on Thu Mar 26 01:21:08 EDT 2020
TRANSPORTER -> INHIBITOR
Mediator Substance Details
none
Created by admin on Thu Mar 26 01:21:12 EDT 2020 , Edited by admin on Thu Mar 26 01:21:12 EDT 2020
TARGET -> INHIBITOR
none
Mediator Substance Details
none
Created by admin on Thu Mar 26 01:21:06 EDT 2020 , Edited by admin on Thu Mar 26 01:21:06 EDT 2020
TRANSPORTER -> SUBSTRATE
none
Mediator Substance Details
none
Created by admin on Thu Mar 26 01:21:12 EDT 2020 , Edited by admin on Thu Mar 26 01:21:12 EDT 2020
TRANSPORTER -> INHIBITOR
none
Mediator Substance Details
none
Created by admin on Thu Mar 26 01:21:11 EDT 2020 , Edited by admin on Thu Mar 26 01:21:11 EDT 2020
TRANSPORTER -> INDUCER
none
Mediator Substance Details
none
Created by admin on Thu Mar 26 01:21:12 EDT 2020 , Edited by admin on Thu Mar 26 01:21:12 EDT 2020
TRANSPORTER -> SUBSTRATE
none
Mediator Substance Details
none
Created by admin on Thu Mar 26 01:51:20 EDT 2020 , Edited by admin on Thu Mar 26 01:51:20 EDT 2020
Related Record Type Details References
ACTIVE MOIETY
none
none
Mediator Substance Details
none
Created by admin on Thu Mar 26 01:21:06 EDT 2020 , Edited by admin on Thu Mar 26 01:21:06 EDT 2020
Name Property Type Amount Referenced Substance Defining Parameters References
Tmax PHARMACOKINETIC ORAL ADMINISTRATION

Biological Half-life PHARMACOKINETIC
Volume of Distribution PHARMACOKINETIC AT STEADY-STATE

INTRAVENOUS ADMINISTRATION

ORAL BIOAVAILABILITY PHARMACOKINETIC
Note References
[Validation]WARNING:Code 'N0000175605'[NDF-RT] collides (possible duplicate) with existing code & codeSystem for substance:
[I42748ELQW]ACALABRUTINIB
Created Thu Mar 26 01:21:06 EDT 2020
Created By admin
Last Edited Thu Mar 26 01:21:06 EDT 2020
Last Edited By admin
Index Source Text / Citation Source Type Tags Date Accessed File
1 USP DICTIONARY 2010 SRS NOMEN
2 NDF-RT SRS NOMEN
3 https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/21-399_IRESSA_Clinr.pdf NDA PUBLIC REVIEW PUBLIC_DOMAIN_RELEASE
4 GSRS System-generated Validation messages VALIDATION_MESSAGE Thu Mar 26 01:21:06 EDT 2020
5 HTTP://WWW.TANDFONLINE.COM/DOI/PDF/10.1517/17425255.2015.1006626 WEBSITE NOMEN
6 USP Dictionary 2010 SRS NOMEN
7 USAN COUN 2001 USANCOUN NOMEN PUBLIC_DOMAIN_RELEASE
8 Generated from relationship on:'OCT-2' SYSTEM
9 GEFITINIB [MI] SRS_LOCATOR
10 WHO-DD SRS NOMEN
11 MERCK INDEX SRS NOMEN
12 USP DICTIONARY 2011 SRS NOMEN
13 GEFITINIB [VANDF] SRS_LOCATOR
14 https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/21-399_IRESSA_Clinr.pdf NDA PUBLIC REVIEW PUBLIC_DOMAIN_RELEASE
15 INN 2010 SRS NOMEN
16 Generated from relationship on:'ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2' SYSTEM
17 HTTP://WWW.TANDFONLINE.COM/DOI/PDF/10.1517/17425255.2015.1006626 WEBSITE NOMEN
18 Generated from relationship on:'MULTIDRUG RESISTANCE PROTEIN 1' SYSTEM
19 HTTP://WWW.TANDFONLINE.COM/DOI/PDF/10.1517/17425255.2015.1006626 WEBSITE NOMEN
20 Generated from relationship on:'OCT-2' SYSTEM
21 GEFITINIB [USAN] SRS_LOCATOR
22 EMA SRS NOMEN
23 https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/021399lbl.pdf NDA PUBLIC REVIEW PUBLIC_DOMAIN_RELEASE
24 https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/21-399_IRESSA_Clinr.pdf NDA PUBLIC REVIEW PUBLIC_DOMAIN_RELEASE
25 GEFITINIB [MART.] SRS_LOCATOR
26 https://www.accessdata.fda.gov/drugsatfda_docs/nda/2003/21-399_IRESSA_Clinr.pdf NDA PUBLIC REVIEW PUBLIC_DOMAIN_RELEASE
27 WEBSITE WEBSITE NOMEN PUBLIC_DOMAIN_RELEASE
28 GEFITINIB [WHO-DD] SRS_LOCATOR
29 Generated from relationship on:'OCT-3' SYSTEM
30 GEFITINIB [INN] SRS_LOCATOR
31 STN STN (SCIFINDER)
32 MARTINDALE 2011 SRS NOMEN
33 DRUG METABOLISM HANDBOOK, ED. A.F. NASSER, 2009, PG:91 BOOK NOMEN
34 SYSTEM
35 KEGG 2011 SRS NOMEN
36 HTTP://WWW.TANDFONLINE.COM/DOI/PDF/10.1517/17425255.2015.1006626 WEBSITE NOMEN
37 HTTP://WWW.TANDFONLINE.COM/DOI/PDF/10.1517/17425255.2015.1006626 WEBSITE NOMEN
38 Generated from relationship on:'OATP1B1' SYSTEM
39 GEFITINIB [JAN] SRS_LOCATOR
40 SRS CODE IMPORT SRS NOMEN Fri Apr 28 14:38:11 EDT 2017
41 GEFITINIB [ORANGE BOOK] SRS_LOCATOR
42 KATHAWALA, R.J., ET AL., THE MODULATION OF ABC TRANSPORTER-MEDIATED MULTIDRUG RESISTANCE IN CANCER: A REVIEW OF THE PAST DECADE. DRUG RESIST. UPDAT. (2014), HTTP://DX.DOI.ORG/10.1016/J.DRUP.2014.11.002 CAS NOMEN
43 Generated from relationship on:'OATP-8' SYSTEM
44 Trends in Pharmacological Sciences, November 2014, Vol. 35, No. 11 604-620 WEBSITE NOMEN
45 SRS import [S65743JHBS] SRS NOMEN Fri Apr 28 14:38:11 EDT 2017
46 GEFITINIB [EMA EPAR] SRS_LOCATOR
47 FDA_SRS SRS NOMEN PUBLIC_DOMAIN_RELEASE AUTO_SELECTED
48 GSRS System-generated Validation messages VALIDATION_MESSAGE Thu Mar 26 01:21:06 EDT 2020
49 ORANGE BOOK 2011 SRS NOMEN
50 WEBSITE WEBSITE NOMEN PUBLIC_DOMAIN_RELEASE

Version

Version Comments

Editor

Change Date

25
admin
Wed Mar 25 21:51:20 EDT 2020

Molecular Formula C22H24ClFN4O3
Molecular Weight 446.902
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE