Basic Searches
Searches without any special characters (listed below) will return items that contain the exact value(s) entered in the search field. This means that searching for "ASPIRIN CALCIUM" won't return any items that have "ASPIRIN GLYCINE CALCIUM" because the search term doesn't match exactly.
Boolean Operators
OR - searches with terms separated by " OR " will return items that contain any of the terms in the search.
Example: "ASPIRIN" OR "CALCIUM" will return items that have strings like "ASPIRIN GLYCINE" and "GLYCINE CALCIUM" because they contain at least one of the terms in the search.

AND - searches with terms separated by " AND " will return items that contain all the terms in the search.
Example: "ASPIRIN" AND "CALCIUM" won't return items that have strings "ASPIRIN GLYCINE" and "GLYCINE CALCIUM" because neither contain both terms, but it will return "ASPIRIN GLYCINE CALCIUM" because it contains both search terms.
version 2.5
Substance Class Chemical
Record UNII
OEI6OOU6IK
Record Status Validated (UNII)
Record Version
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Details

Stereochemistry ACHIRAL
Molecular Formula C23H21Cl2FN4O3
Molecular Weight 491.342
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0
Created by admin on Thu Mar 26 02:10:49 EDT 2020
Edited by admin on Thu Mar 26 02:10:49 EDT 2020
Structure of POZIOTINIB

Systematic Names:

  • None recorded
  • {{name}}

SMILES

COC1=CC2=NC=NC(NC3=CC=C(Cl)C(Cl)=C3F)=C2C=C1OC4CCN(CC4)C(=O)C=C

InChI

LPFWVDIFUFFKJU-UHFFFAOYSA-N
InChI=1S/C23H21Cl2FN4O3/c1-3-20(31)30-8-6-13(7-9-30)33-19-10-14-17(11-18(19)32-2)27-12-28-23(14)29-16-5-4-15(24)21(25)22(16)26/h3-5,10-13H,1,6-9H2,2H3,(H,27,28,29)
Name Type Language Details References
POZIOTINIB
Domain Jurisdiction Naming Organization
drug  
INN  
INN   WHO-DD  
Official Name
English  
POZIOTINIB [WHO-DD]
Common Name
English  
2-PROPEN-1-ONE, 1-(4-((4-((3,4-DICHLORO-2-FLUOROPHENYL)AMINO)-7-METHOXY-6-QUINAZOLINYL)OXY)-1-PIPERIDINYL)-
Systematic Name
English  
1-(4-((4-(3,4-DICHLORO-2-FLUOROANILINO)-7-METHOXYQUINAZOLIN-6-YL)OXY(PIPERIDIN-1-YL)PROP-2-EN-1-ONE
Common Name
English  
HM-781-36
Code
English  
NOV-120101
Code
English  
POZIOTINIB [INN]
Common Name
English  
HM 781-36
Code
English  
Classification Tree Code System Code References
NCI_THESAURUS C1742
Created by admin on Thu Mar 26 02:10:49 EDT 2020 , Edited by admin on Thu Mar 26 02:10:49 EDT 2020
NCI_THESAURUS C2167
Created by admin on Thu Mar 26 02:10:49 EDT 2020 , Edited by admin on Thu Mar 26 02:10:49 EDT 2020
NCI_THESAURUS C129825
Created by admin on Thu Mar 26 02:10:49 EDT 2020 , Edited by admin on Thu Mar 26 02:10:49 EDT 2020
Code System Code Type Description References
CAS
1092364-38-9
Created by admin on Thu Mar 26 02:10:49 EDT 2020 , Edited by admin on Thu Mar 26 02:10:49 EDT 2020
PRIMARY
ChEMBL
CHEMBL3545154
Created by admin on Thu Mar 26 02:10:49 EDT 2020 , Edited by admin on Thu Mar 26 02:10:49 EDT 2020
PRIMARY
PUBCHEM
25127713
Created by admin on Thu Mar 26 02:10:49 EDT 2020 , Edited by admin on Thu Mar 26 02:10:49 EDT 2020
PRIMARY
EPA CompTox
1092364-38-9
Created by admin on Thu Mar 26 02:10:49 EDT 2020 , Edited by admin on Thu Mar 26 02:10:49 EDT 2020
PRIMARY
NCI_THESAURUS
C98838
Created by admin on Thu Mar 26 02:10:49 EDT 2020 , Edited by admin on Thu Mar 26 02:10:49 EDT 2020
PRIMARY
INN
9736
Created by admin on Thu Mar 26 02:10:49 EDT 2020 , Edited by admin on Thu Mar 26 02:10:49 EDT 2020
PRIMARY
Related Record Type Details References
TARGET -> INHIBITOR
none
Mediator Substance Details
none
Created by admin on Thu Mar 26 02:10:49 EDT 2020 , Edited by admin on Thu Mar 26 02:10:49 EDT 2020
TARGET -> INHIBITOR
none
Mediator Substance Details
none
Created by admin on Thu Mar 26 02:10:49 EDT 2020 , Edited by admin on Thu Mar 26 02:10:49 EDT 2020
TARGET -> INHIBITOR
none
Mediator Substance Details
none
Created by admin on Thu Mar 26 02:10:49 EDT 2020 , Edited by admin on Thu Mar 26 02:10:49 EDT 2020
SALT/SOLVATE -> PARENT
none
Mediator Substance Details
none
Created by admin on Thu Mar 26 02:10:49 EDT 2020 , Edited by admin on Thu Mar 26 02:10:49 EDT 2020
Related Record Type Details References
ACTIVE MOIETY
none
none
Mediator Substance Details
none
Created by admin on Thu Mar 26 02:10:50 EDT 2020 , Edited by admin on Thu Mar 26 02:10:50 EDT 2020
Note References
[Validation]WARNING:Structure has 1 possible duplicate:
[X4Z7U6JL1C]POZIOTINIB HYDROCHLORIDE
Created Thu Mar 26 02:10:49 EDT 2020
Created By admin
Last Edited Thu Mar 26 02:10:49 EDT 2020
Last Edited By admin
Index Source Text / Citation Source Type Tags Date Accessed File
1 FDA_SRS SRS NOMEN
2 GSRS System-generated Validation messages VALIDATION_MESSAGE Thu Mar 26 02:10:49 EDT 2020
3 STN STN (SCIFINDER) NOMEN
4 INN SRS NOMEN PUBLIC_DOMAIN_RELEASE AUTO_SELECTED
5 STN STN (SCIFINDER)
6 NCIT NCI THESAURUS PUBLIC_DOMAIN_RELEASE NOMEN
7 POZIOTINIB [WHO-DD] SRS_LOCATOR
8 GSRS System-generated Validation messages VALIDATION_MESSAGE Thu Mar 26 02:10:49 EDT 2020
9 Kim, Tae-Yong, et al. "A phase I/II study of poziotinib combined with paclitaxel and trastuzumab in patients with HER2-positive advanced gastric cancer." Gastric Cancer (2019): 1-9. JA CLIN NOMEN POT
10 SYSTEM
11 Kim, Eunyoung, et al. "Metabolite identification of a new tyrosine kinase inhibitor, HM781€?36B, and a pharmacokinetic study by liquid chromatography/tandem mass spectrometry." Rapid Communications in Mass Spectrometry 27.11 (2013): 1183-1195. JA NOMEN PUBLIC_DOMAIN_RELEASE
12 INN INN NOMEN
13 STN SRS NOMEN
14 WHO-DD SRS NOMEN
15 WEBSITE WEBSITE NOMEN PUBLIC_DOMAIN_RELEASE
16 SRS import [OEI6OOU6IK] SRS NOMEN Fri Apr 28 15:05:36 EDT 2017
17 CHEMBL SRS NOMEN
18 SRS CODE IMPORT SRS NOMEN Fri Apr 28 15:05:36 EDT 2017
19 POZIOTINIB [INN] SRS_LOCATOR
20 Kim, Eunyoung, et al. "Metabolite identification of a new tyrosine kinase inhibitor, HM781€?36B, and a pharmacokinetic study by liquid chromatography/tandem mass spectrometry." Rapid Communications in Mass Spectrometry 27.11 (2013): 1183-1195. JA NOMEN

Molecular Formula C23H21Cl2FN4O3
Molecular Weight 491.342
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE