Basic Searches
Searches without any special characters (listed below) will return items that contain the exact value(s) entered in the search field. This means that searching for "ASPIRIN CALCIUM" won't return any items that have "ASPIRIN GLYCINE CALCIUM" because the search term doesn't match exactly.
Boolean Operators
OR - searches with terms separated by " OR " will return items that contain any of the terms in the search.
Example: "ASPIRIN" OR "CALCIUM" will return items that have strings like "ASPIRIN GLYCINE" and "GLYCINE CALCIUM" because they contain at least one of the terms in the search.

AND - searches with terms separated by " AND " will return items that contain all the terms in the search.
Example: "ASPIRIN" AND "CALCIUM" won't return items that have strings "ASPIRIN GLYCINE" and "GLYCINE CALCIUM" because neither contain both terms, but it will return "ASPIRIN GLYCINE CALCIUM" because it contains both search terms.
version 2.5
Substance Class Protein
Protein Type MONOCLONAL ANTIBODY CONJUGATE
Protein Sub Type IGG1
Sequence Origin CHIMERIC/HUMANIZED MOUSE
Sequence Type COMPLETE
Record UNII
F3R7A4P04N
Record Status Validated (UNII)
Record Version
Show Definitional References Hide Definitional References
Download
Name Type Language Details References
DEPATUXIZUMAB MAFODOTIN
Domain Jurisdiction Naming Organization
drug  
INN   USAN  
INN   USAN   WHO-DD  
Official Name
English  
IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS EGFR (EPIDERMAL GROWTH FACTOR RECEPTOR, RECEPTOR TYROSINE-PROTEIN KINASE ERBB-1, ERBB1, HER1, HER-1, ERBB)), HUMANIZED AND CHIMERIC MONOCLONAL ANTIBODY CONJUGATED TO AURISTATIN F
Systematic Name
English  
IMMUNOGLOBULIN G1, ANTI-(HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR) (HUMAN-MUS MUSCULUS MONOCLONAL ABT-806 HEAVY CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL ABT-806 LIGHT CHAIN, DIMER, TETRAKIS(THIOETHER) WITH N-(6-(3-MERCAPTO-2,5-DIOXO-1-PYRROLIDI
Systematic Name
English  
DEPATUXIZUMAB MAFODOTIN [WHO-DD]
Common Name
English  
DEPATUXIZUMAB MAFODOTIN [INN]
Common Name
English  
ABT-414
Code
English  
DEPATUXIZUMAB MAFODOTIN [USAN]
Common Name
English  
Classification Tree Code System Code References
FDA ORPHAN DRUG 433214
Created by admin on Thu Mar 26 03:05:56 EDT 2020 , Edited by admin on Thu Mar 26 03:05:56 EDT 2020
NCI_THESAURUS C129825
Created by admin on Thu Mar 26 03:05:56 EDT 2020 , Edited by admin on Thu Mar 26 03:05:56 EDT 2020
NCI_THESAURUS C2167
Created by admin on Thu Mar 26 03:05:56 EDT 2020 , Edited by admin on Thu Mar 26 03:05:56 EDT 2020
Code System Code Type Description References
WIKIPEDIA
DEPATUXIZUMAB MAFODOTIN
Created by admin on Thu Mar 26 03:05:56 EDT 2020 , Edited by admin on Thu Mar 26 03:05:56 EDT 2020
PRIMARY
ChEMBL
CHEMBL3707277
Created by admin on Thu Mar 26 03:05:56 EDT 2020 , Edited by admin on Thu Mar 26 03:05:56 EDT 2020
PRIMARY
CAS
1585973-65-4
Created by admin on Thu Mar 26 03:05:56 EDT 2020 , Edited by admin on Thu Mar 26 03:05:56 EDT 2020
PRIMARY
INN
10263
Created by admin on Thu Mar 26 03:05:56 EDT 2020 , Edited by admin on Thu Mar 26 03:05:56 EDT 2020
PRIMARY
EVMPD
SUB181033
Created by admin on Thu Mar 26 03:05:56 EDT 2020 , Edited by admin on Thu Mar 26 03:05:56 EDT 2020
PRIMARY
PUBCHEM
86278355
Created by admin on Thu Mar 26 03:05:56 EDT 2020 , Edited by admin on Thu Mar 26 03:05:56 EDT 2020
PRIMARY
From To
1_22 1_96
1_143 1_199
1_219 3_214
1_225 2_225
1_228 2_228
1_260 1_320
1_366 1_424
2_22 2_96
2_143 2_199
2_219 4_214
2_260 2_320
2_366 2_424
3_23 3_88
3_134 3_194
4_23 4_88
4_134 4_194
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_296
N 2_296
Related Record Type Details References
CONJUGATE COMPONENT->CONJUGATE
none
Mediator Substance Details
none
Created by admin on Thu Mar 26 03:05:58 EDT 2020 , Edited by admin on Thu Mar 26 03:05:58 EDT 2020
TARGET->LIGAND
none
Mediator Substance Details
none
Created by admin on Thu Mar 26 03:05:56 EDT 2020 , Edited by admin on Thu Mar 26 03:05:56 EDT 2020
CONJUGATE COMPONENT->CONJUGATE
none
none
Mediator Substance Details
none
Created by admin on Thu Mar 26 03:05:58 EDT 2020 , Edited by admin on Thu Mar 26 03:05:58 EDT 2020
TARGET -> INHIBITOR
none
Mediator Substance Details
none
Created by admin on Thu Mar 26 03:05:58 EDT 2020 , Edited by admin on Thu Mar 26 03:05:58 EDT 2020
Related Record Type Details References
ACTIVE MOIETY
none
none
Mediator Substance Details
none
Created by admin on Thu Mar 26 03:05:56 EDT 2020 , Edited by admin on Thu Mar 26 03:05:56 EDT 2020
Structural Modifications
Modification Type Location Site Location Type Residue Modified Extent Modification Name Modification ID
AMINO ACID SUBSTITUTION 1_1; 2_1 PIDOLIC ACID SZB83O1W42
AMINO ACID SUBSTITUTION [1_219] [1_225] [1_228] [2_219] [2_225] [2_228] [3_214] [4_214] C
Amount:
CYSTEINYL-MAFODOTIN B4S8ET206U
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:CALCULATED CHEMICAL 0
Note References
[Validation]WARNING:There are 8 substances with a similar sequence to subunit [3,4]:
(Perform similarity search on subunit [3])
found exact duplicate (100%) sequence in Subunit [3] of "RY62FD82YX" ("SERCLUTAMAB")
found exact duplicate (100%) sequence in Subunit [4] of "RY62FD82YX" ("SERCLUTAMAB")
found exact duplicate (100%) sequence in Subunit [3] of "17C83BVV62" ("LOSATUXIZUMAB VEDOTIN")
found exact duplicate (100%) sequence in Subunit [4] of "17C83BVV62" ("LOSATUXIZUMAB VEDOTIN")
found exact duplicate (100%) sequence in Subunit [3] of "28TZY9G26X" ("LOSATUXIZUMAB")
found exact duplicate (100%) sequence in Subunit [4] of "28TZY9G26X" ("LOSATUXIZUMAB")
found exact duplicate (100%) sequence in Subunit [3] of "7W0O278T12" ("SERCLUTAMAB TALIRINE")
found exact duplicate (100%) sequence in Subunit [4] of "7W0O278T12" ("SERCLUTAMAB TALIRINE")
[Validation]WARNING:There are 10 substances with a similar sequence to subunit [1,2]:
(Perform similarity search on subunit [1])
found approximate duplicate (95%) sequence in Subunit [1] of "FC1ZF28VIT" ("ETIGILIMAB")
found approximate duplicate (95%) sequence in Subunit [2] of "FC1ZF28VIT" ("ETIGILIMAB")
found approximate duplicate (98%) sequence in Subunit [2] of "RY62FD82YX" ("SERCLUTAMAB")
found approximate duplicate (98%) sequence in Subunit [1] of "RY62FD82YX" ("SERCLUTAMAB")
found approximate duplicate (98%) sequence in Subunit [1] of "7W0O278T12" ("SERCLUTAMAB TALIRINE")
found approximate duplicate (98%) sequence in Subunit [2] of "7W0O278T12" ("SERCLUTAMAB TALIRINE")
found approximate duplicate (99%) sequence in Subunit [2] of "28TZY9G26X" ("LOSATUXIZUMAB")
found approximate duplicate (99%) sequence in Subunit [2] of "17C83BVV62" ("LOSATUXIZUMAB VEDOTIN")
found approximate duplicate (99%) sequence in Subunit [1] of "17C83BVV62" ("LOSATUXIZUMAB VEDOTIN")
found approximate duplicate (99%) sequence in Subunit [1] of "28TZY9G26X" ("LOSATUXIZUMAB")
[Validation]WARNING:Code '86278355'[PUBCHEM] collides (possible duplicate) with existing code & codeSystem for substance:
[B4S8ET206U]CYSTEINYL-MAFODOTIN
Created Thu Mar 26 03:05:56 EDT 2020
Created By admin
Last Edited Thu Mar 26 03:05:56 EDT 2020
Last Edited By admin
Index Source Text / Citation Source Type Tags Date Accessed File
1 DEPATUXIZUMAB MAFODOTIN [USAN] SRS_LOCATOR
2 SYSTEM
3 DEPATUXIZUMAB MAFODOTIN [WHO-DD] SRS_LOCATOR
4 STN STN (SCIFINDER)
5 https://en.wikipedia.org/wiki/Depatuxizumab_mafodotin WEBSITE NOMEN
6 USAN SRS NOMEN PUBLIC_DOMAIN_RELEASE AUTO_SELECTED
7 https://adisinsight.springer.com/drugs/800020744 WEB PAGE
8 USAN COUN 2016 SRS NOMEN
9 SRS import [F3R7A4P04N] SRS NOMEN Fri Apr 28 15:21:27 EDT 2017
10 GSRS System-generated Validation messages VALIDATION_MESSAGE Thu Mar 26 03:05:54 EDT 2020
11 INN SRS NOMEN
12 DEPATUXIZUMAB MAFODOTIN [INN] SRS_LOCATOR
13 WHO-DD SRS NOMEN
14 STN SRS NOMEN
15 SRS CODE IMPORT SRS NOMEN Fri Apr 28 15:21:27 EDT 2017
16 GSRS System-generated Validation messages VALIDATION_MESSAGE Thu Mar 26 03:05:54 EDT 2020