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Searches without any special characters (listed below) will return items that contain the exact value(s) entered in the search field. This means that searching for "ASPIRIN CALCIUM" won't return any items that have "ASPIRIN GLYCINE CALCIUM" because the search term doesn't match exactly.
Boolean Operators
OR - searches with terms separated by " OR " will return items that contain any of the terms in the search.
Example: "ASPIRIN" OR "CALCIUM" will return items that have strings like "ASPIRIN GLYCINE" and "GLYCINE CALCIUM" because they contain at least one of the terms in the search.

AND - searches with terms separated by " AND " will return items that contain all the terms in the search.
Example: "ASPIRIN" AND "CALCIUM" won't return items that have strings "ASPIRIN GLYCINE" and "GLYCINE CALCIUM" because neither contain both terms, but it will return "ASPIRIN GLYCINE CALCIUM" because it contains both search terms.
version 2.3.3
Substance Class Chemical
Record UNII
DU69T8ZZPA
Record Status Validated (UNII)
Record Version
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Details

Stereochemistry ABSOLUTE
Molecular Formula C37H47NO12
Molecular Weight 697.7686
Optical Activity UNSPECIFIED
Defined Stereocenters 9 / 9
E/Z Centers 0
Charge 0
Created by admin on Wed Apr 03 19:44:46 EDT 2019
Edited by admin on Wed Apr 03 19:44:46 EDT 2019
Structure of RIFAMYCIN

Systematic Names:

  • None recorded
  • {{name}}

SMILES

CO[C@H]1\C=C\O[C@@]2(C)OC3=C(C)C(O)=C4C(O)=C(NC(=O)C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)C=C(O)C4=C3C2=O

InChI

InChIKey=HJYYPODYNSCCOU-ODRIEIDWSA-N
InChI=1S/C37H47NO12/c1-16-11-10-12-17(2)36(46)38-23-15-24(40)26-27(32(23)44)31(43)21(6)34-28(26)35(45)37(8,50-34)48-14-13-25(47-9)18(3)33(49-22(7)39)20(5)30(42)19(4)29(16)41/h10-16,18-20,25,29-30,33,40-44H,1-9H3,(H,38,46)/b11-10+,14-13+,17-12-/t16-,18+,19+,20+,25-,29-,30+,33+,37-/m0/s1
Name Type Language References
RIFAMYCIN
INN   USAN   WHO-DD  
USAN   INN  
Official Name
English  
M-14
Code
English  
RIFAMYCIN [WHO-DD]
Common Name
English  
RIFAMYCIN SV
MI  
Common Name
English  
RIFAMICINE SV
Common Name
English  
5,6,9,17,19,21-HEXAHYDROXY-23-METHOXY-2,4,12,16,18,20,22-HEPTAMETHYL-2,7-(EPOXYPENTADECA(1,11,13)TRIENIMINO)NAPHTHO(2,1-B)FURAN-1,11(2H)-DIONE 21-ACETATE
Common Name
English  
RIFAMYCIN [USAN]
Common Name
English  
RIFAMYCIN SV, AN ANTIBIOTIC PRODUCED BY CERTAIN STRAINS OF STREPTOMYCES MEDITERRANEI, OR THE SAME SUBSTANCE PRODUCED BY ANY OTHER MEANS
Common Name
English  
RIFAMYCIN [INN]
Common Name
English  
RIFAMYCIN SV [MI]
Common Name
English  
RIFOMYCIN SV
Common Name
English  
Classification Tree Code System Code References
WHO-VATC QJ04AB03
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
WHO-ATC S01AA16
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
WHO-VATC QJ54AB03
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
WHO-ATC J04AB03
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
NCI_THESAURUS C280
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
WHO-ATC S02AA12
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
WHO-VATC QS01AA16
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
WHO-VATC QS02AA12
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
Code System Code Type Description References
EVMPD
SUB10310MIG
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
PRIMARY
WIKIPEDIA
Rifamycin
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
PRIMARY
NCI_THESAURUS
C29406
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
PRIMARY
MESH
C023808
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
PRIMARY
ECHA (EC/EINECS)
230-273-3
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
PRIMARY
EPA CompTox
6998-60-3
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
PRIMARY
RXCUI
35616
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
PRIMARY RxNorm
MERCK INDEX
M9613
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
PRIMARY Merck Index
PUBCHEM
6324616
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
PRIMARY SWITZERF
CAS
6998-60-3
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
PRIMARY
ChEMBL
CHEMBL437765
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
PRIMARY
INN
2293
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
PRIMARY
Related Record Type Details References
TRANSPORTER -> INHIBITOR
Mediator Substance Details
none
Rifamycin is an inhibitor of renal transporters organic anion transporter (OAT) 3, multidrug and toxin extrusion (MATE) 1, and MATE2-K transporters in vitro, however, based on systemic concentrations of rifamycin observed after administration of the recommended dose, clinically relevant inhibition of these transporters in vivo is unlikely.
Created by admin on Wed Apr 03 19:44:47 EDT 2019 , Edited by admin on Wed Apr 03 19:44:47 EDT 2019
METABOLIC ENZYME -> INDUCER
Mediator Substance Details
none
Rifamycin is an inducer of CYP3A4 and CYP2B6 but not CYP1A2 in vitro, however, based on systemic concentrations of rifamycin observed after administration of the recommended dose, clinically relevant induction of these enzymes in vivo is unlikely.
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
TARGET ORGANISM->INHIBITOR
Mediator Substance Details
none
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
METABOLIC ENZYME -> INHIBITOR
Mediator Substance Details
none
Rifamycin is an inhibitor of CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6 and 3A4/5 in vitro, however, based on systemic concentrations of rifamycin observed after administration of the recommended dose clinically relevant inhibition of these enzymes in vivo is unlikely.
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
METABOLIC ENZYME -> INHIBITOR
Mediator Substance Details
none
Rifamycin is an inhibitor of CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6 and 3A4/5 in vitro, however, based on systemic concentrations of rifamycin observed after administration of the recommended dose clinically relevant inhibition of these enzymes in vivo is unlikely.
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
TRANSPORTER -> INHIBITOR
Mediator Substance Details
none
Created by admin on Wed Apr 03 19:58:53 EDT 2019 , Edited by admin on Wed Apr 03 19:58:53 EDT 2019
TARGET ORGANISM->INHIBITOR
Mediator Substance Details
none
Other
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
METABOLIC ENZYME -> INDUCER
Mediator Substance Details
none
Rifamycin is an inducer of CYP3A4 and CYP2B6 but not CYP1A2 in vitro, however, based on systemic concentrations of rifamycin observed after administration of the recommended dose, clinically relevant induction of these enzymes in vivo is unlikely.
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
TRANSPORTER -> INHIBITOR
Mediator Substance Details
none
Rifamycin is an inhibitor of renal transporters organic anion transporter (OAT) 3, multidrug and toxin extrusion (MATE) 1, and MATE2-K transporters in vitro, however, based on systemic concentrations of rifamycin observed after administration of the recommended dose, clinically relevant inhibition of these transporters in vivo is unlikely.
Created by admin on Wed Apr 03 19:44:47 EDT 2019 , Edited by admin on Wed Apr 03 19:44:47 EDT 2019
TRANSPORTER -> INHIBITOR
Mediator Substance Details
none
IC50
Created by admin on Wed Apr 03 19:44:47 EDT 2019 , Edited by admin on Wed Apr 03 19:44:47 EDT 2019
TARGET ORGANISM->INHIBITOR
Mediator Substance Details
none
Created by admin on Wed Apr 03 19:44:47 EDT 2019 , Edited by admin on Wed Apr 03 19:44:47 EDT 2019
TRANSPORTER -> INHIBITOR
Mediator Substance Details
none
Created by admin on Thu Apr 04 01:33:31 EDT 2019 , Edited by admin on Thu Apr 04 01:33:31 EDT 2019
METABOLIC ENZYME -> INHIBITOR
Mediator Substance Details
none
Rifamycin is an inhibitor of CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6 and 3A4/5 in vitro, however, based on systemic concentrations of rifamycin observed after administration of the recommended dose clinically relevant inhibition of these enzymes in vivo is unlikely.
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
TRANSPORTER -> SUBSTRATE
Mediator Substance Details
none
Created by admin on Wed Apr 03 19:44:47 EDT 2019 , Edited by admin on Wed Apr 03 19:44:47 EDT 2019
EXCRETED UNCHANGED
Mediator Substance Details
none
After IV administration of rifamycin SV, > 90% of the dose is excreted as unchanged drug in feces via biliary secretion8
FECAL
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
TRANSPORTER -> INHIBITOR
Mediator Substance Details
none
IC50
Created by admin on Wed Apr 03 19:44:47 EDT 2019 , Edited by admin on Wed Apr 03 19:44:47 EDT 2019
TRANSPORTER -> INHIBITOR
Mediator Substance Details
none
Created by admin on Wed Apr 03 20:39:15 EDT 2019 , Edited by admin on Wed Apr 03 20:39:15 EDT 2019
METABOLIC ENZYME -> INHIBITOR
Mediator Substance Details
none
Rifamycin is an inhibitor of CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6 and 3A4/5 in vitro, however, based on systemic concentrations of rifamycin observed after administration of the recommended dose clinically relevant inhibition of these enzymes in vivo is unlikely.
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
METABOLIC ENZYME -> NON-SUBSTRATE
Mediator Substance Details
none
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
TRANSPORTER -> INHIBITOR
Mediator Substance Details
none
Rifamycin is an inhibitor of renal transporters organic anion transporter (OAT) 3, multidrug and toxin extrusion (MATE) 1, and MATE2-K transporters in vitro, however, based on systemic concentrations of rifamycin observed after administration of the recommended dose, clinically relevant inhibition of these transporters in vivo is unlikely.
Created by admin on Wed Apr 03 19:44:47 EDT 2019 , Edited by admin on Wed Apr 03 19:44:47 EDT 2019
METABOLIC ENZYME -> INHIBITOR
Mediator Substance Details
none
Rifamycin is an inhibitor of CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6 and 3A4/5 in vitro, however, based on systemic concentrations of rifamycin observed after administration of the recommended dose clinically relevant inhibition of these enzymes in vivo is unlikely.
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
METABOLIC ENZYME -> INHIBITOR
Mediator Substance Details
none
Rifamycin is an inhibitor of CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6 and 3A4/5 in vitro, however, based on systemic concentrations of rifamycin observed after administration of the recommended dose clinically relevant inhibition of these enzymes in vivo is unlikely.
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
METABOLIC ENZYME -> INHIBITOR
Mediator Substance Details
none
Rifamycin is an inhibitor of CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6 and 3A4/5 in vitro, however, based on systemic concentrations of rifamycin observed after administration of the recommended dose clinically relevant inhibition of these enzymes in vivo is unlikely.
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
Related Record Type Details References
ACTIVE MOIETY
none
Mediator Substance Details
none
Created by admin on Wed Apr 03 19:44:46 EDT 2019 , Edited by admin on Wed Apr 03 19:44:46 EDT 2019
Created Wed Apr 03 19:44:46 EDT 2019
Created By admin
Last Edited Wed Apr 03 19:44:46 EDT 2019
Last Edited By admin
Index Source Text / Citation Source Type Tags Date Accessed
1 https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210910s000lbl.pdf NDA PUBLIC REVIEW PUBLIC_DOMAIN_RELEASE
2 USP Dictionary 2009 SRS NOMEN
3 STN STN (SCIFINDER) PUBLIC_DOMAIN_RELEASE
4 INN 2010 SRS NOMEN
5 Generated from relationship on:'SOLUTE CARRIER FAMILY 21 MEMBER 3' SYSTEM
6 RIFAMYCIN [WHO-DD] SRS_LOCATOR
7 http://dbts.ucsf.edu/fdatransportal/transporters/SLCO1B3/ WEBSITE NOMEN
8 RIFAMYCIN [USAN] SRS_LOCATOR
9 https://www.cdc.gov/tb/publications/guidelines/tb_hiv_drugs/recommendations01.htm WEB PAGE
10 Generated from relationship on:'OATP-8' SYSTEM
11 RIFAMYCIN [INN] SRS_LOCATOR
12 http://dbts.ucsf.edu/fdatransportal/transporters/SLCO2B1/ WEBSITE NOMEN
13 http://www.drugs.com/international/rifocin.html SRS NOMEN
14 SRS CODE IMPORT SRS NOMEN Fri Apr 28 14:27:38 EDT 2017
15 http://bts.ucsf.edu/fdatransportal/transporters/SLCO1A2/ WEBSITE NOMEN
16 RIFAMYCIN SV [MI] SRS_LOCATOR
17 https://www.accessdata.fda.gov/drugsatfda_docs/nda/2018/210910Orig1s000MultidisciplineR.pdf NDA PUBLIC REVIEW PUBLIC_DOMAIN_RELEASE
18 SYSTEM
19 SRS import [DU69T8ZZPA] SRS NOMEN Fri Apr 28 14:27:38 EDT 2017
20 USP DICTIONARY 2009 SRS NOMEN
21 WHO-DD SRS NOMEN
22 WEBSITE WEBSITE NOMEN PUBLIC_DOMAIN_RELEASE
23 USP DICTIONARY 2010 SRS NOMEN
24 Merck SRS NOMEN PUBLIC_DOMAIN_RELEASE AUTO_SELECTED
25 MERCK INDEX MERCK INDEX NOMEN
26 USP DICTIONARY 2011 SRS NOMEN
27 dump-public-2019-04-03.gsrs BATCH_IMPORT Wed Apr 03 19:44:45 EDT 2019
28 MERCK INDEX SRS NOMEN
29 Generated from relationship on:'OATP-B' SYSTEM

Version

Version Comments

Editor

Change Date

9
admin
Wed Apr 03 21:33:31 EDT 2019
8
admin
Wed Apr 03 16:39:15 EDT 2019
7
admin
Wed Apr 03 15:58:53 EDT 2019

Molecular Formula C37H47NO12
Molecular Weight 697.7686
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry
Defined Stereocenters 9 / 9
E/Z Centers 0
Optical Activity UNSPECIFIED