Basic Searches
Searches without any special characters (listed below) will return items that contain the exact value(s) entered in the search field. This means that searching for "ASPIRIN CALCIUM" won't return any items that have "ASPIRIN GLYCINE CALCIUM" because the search term doesn't match exactly.
Boolean Operators
OR - searches with terms separated by " OR " will return items that contain any of the terms in the search.
Example: "ASPIRIN" OR "CALCIUM" will return items that have strings like "ASPIRIN GLYCINE" and "GLYCINE CALCIUM" because they contain at least one of the terms in the search.

AND - searches with terms separated by " AND " will return items that contain all the terms in the search.
Example: "ASPIRIN" AND "CALCIUM" won't return items that have strings "ASPIRIN GLYCINE" and "GLYCINE CALCIUM" because neither contain both terms, but it will return "ASPIRIN GLYCINE CALCIUM" because it contains both search terms.
version 2.5
Substance Class Protein
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type TOXIN CONJUGATE
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
7W0O278T12
Record Status Validated (UNII)
Record Version
Show Definitional References Hide Definitional References
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Name Type Language Details References
SERCLUTAMAB TALIRINE
Domain Jurisdiction Naming Organization
drug  
INN  
Official Name
English  
IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS EGFR (EPIDERMAL GROWTH FACTOR RECEPTOR, RECEPTOR TYROSINE-PROTEIN KINASE ERBB-1, ERBB1, HER1, HER-1, ERBB)), MONOCLONAL ANTIBODY CONJUGATED TO THE PYRROLOBENZODIAZEPINE (PDB) DIMER SGD-1882GAMMA1 HEAVY CHAIN (1
Common Name
English  
SERCLUTAMAB TALIRINE [INN]
Common Name
English  
ANTI-EGFR/PBD ANTIBODY-DRUG CONJUGATE ABBV-321
Common Name
English  
Code System Code Type Description References
NCI_THESAURUS
C150590
Created by admin on Thu Mar 26 00:49:06 EDT 2020 , Edited by admin on Thu Mar 26 00:49:06 EDT 2020
PRIMARY
CAS
2140174-56-5
Created by admin on Thu Mar 26 00:49:06 EDT 2020 , Edited by admin on Thu Mar 26 00:49:06 EDT 2020
PRIMARY
INN
10959
Created by admin on Thu Mar 26 00:49:06 EDT 2020 , Edited by admin on Thu Mar 26 00:49:06 EDT 2020
PRIMARY
From To
1_22 1_96
1_143 1_199
1_219 3_214
1_225 2_225
1_228 2_228
1_260 1_320
1_366 1_424
2_22 2_96
2_143 2_199
2_219 4_214
2_260 2_320
2_366 2_424
3_23 3_88
3_134 3_194
4_23 4_88
4_134 4_194
Glycosylation Link Type Site
N 1_296
N 2_296
Related Record Type Details References
CONJUGATE COMPONENT->CONJUGATE
none
none
Mediator Substance Details
none
Created by admin on Thu Mar 26 00:49:06 EDT 2020 , Edited by admin on Thu Mar 26 00:49:06 EDT 2020
TARGET->CONJUGATED TOXIN
none
none
Mediator Substance Details
none
Created by admin on Thu Mar 26 00:49:06 EDT 2020 , Edited by admin on Thu Mar 26 00:49:06 EDT 2020
Related Record Type Details References
ACTIVE MOIETY
none
none
Mediator Substance Details
none
Created by admin on Thu Mar 26 00:49:06 EDT 2020 , Edited by admin on Thu Mar 26 00:49:06 EDT 2020
Structural Modifications
Modification Type Location Site Location Type Residue Modified Extent Modification Name Modification ID
AMINO_ACID_SUBSTITUTION [1_238] [2_238] SITE_SPECIFIC CYSTEINYL TALIRINE X1TW58ZV0U
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL 0
Note References
[Validation]WARNING:There are 2 substances with a similar sequence to subunit [1,2]:
(Perform similarity search on subunit [1])
found exact duplicate (100%) sequence in Subunit [1] of "RY62FD82YX" ("SERCLUTAMAB")
found exact duplicate (100%) sequence in Subunit [2] of "RY62FD82YX" ("SERCLUTAMAB")
[Validation]WARNING:There are 6 substances with a similar sequence to subunit [3,4]:
(Perform similarity search on subunit [3])
found exact duplicate (100%) sequence in Subunit [3] of "17C83BVV62" ("LOSATUXIZUMAB VEDOTIN")
found exact duplicate (100%) sequence in Subunit [4] of "17C83BVV62" ("LOSATUXIZUMAB VEDOTIN")
found exact duplicate (100%) sequence in Subunit [3] of "28TZY9G26X" ("LOSATUXIZUMAB")
found exact duplicate (100%) sequence in Subunit [4] of "28TZY9G26X" ("LOSATUXIZUMAB")
found exact duplicate (100%) sequence in Subunit [3] of "RY62FD82YX" ("SERCLUTAMAB")
found exact duplicate (100%) sequence in Subunit [4] of "RY62FD82YX" ("SERCLUTAMAB")
[Validation]WARNING:Protein needs at least 1 reference
Created Thu Mar 26 00:49:06 EDT 2020
Created By admin
Last Edited Thu Mar 26 00:49:06 EDT 2020
Last Edited By admin
Index Source Text / Citation Source Type Tags Date Accessed File
1 https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C150590 NCI THESAURUS PUBLIC_DOMAIN_RELEASE NOMEN
2 GSRS System-generated Validation messages VALIDATION_MESSAGE Thu Mar 26 00:49:05 EDT 2020
3 GSRS System-generated Validation messages VALIDATION_MESSAGE Thu Mar 26 00:49:05 EDT 2020
4 STN STN (SCIFINDER) NOMEN PUBLIC_DOMAIN_RELEASE
5 Assumed or asserted SYSTEM
6 INN 120 INN_LIST NOMEN PUBLIC_DOMAIN_RELEASE