Basic Searches
Searches without any special characters (listed below) will return items that contain the exact value(s) entered in the search field. This means that searching for "ASPIRIN CALCIUM" won't return any items that have "ASPIRIN GLYCINE CALCIUM" because the search term doesn't match exactly.
Boolean Operators
OR - searches with terms separated by " OR " will return items that contain any of the terms in the search.
Example: "ASPIRIN" OR "CALCIUM" will return items that have strings like "ASPIRIN GLYCINE" and "GLYCINE CALCIUM" because they contain at least one of the terms in the search.

AND - searches with terms separated by " AND " will return items that contain all the terms in the search.
Example: "ASPIRIN" AND "CALCIUM" won't return items that have strings "ASPIRIN GLYCINE" and "GLYCINE CALCIUM" because neither contain both terms, but it will return "ASPIRIN GLYCINE CALCIUM" because it contains both search terms.
version 2.5
Substance Class Chemical
Record UNII
67SX9H68W2
Record Status Validated (UNII)
Record Version
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Details

Stereochemistry ABSOLUTE
Molecular Formula C22H23ClFN5O3
Molecular Weight 459.901
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0
Created by admin on Thu Mar 26 02:24:25 EDT 2020
Edited by admin on Thu Mar 26 02:24:25 EDT 2020
Structure of ZORIFERTINIB

Systematic Names:

  • None recorded
  • {{name}}

SMILES

COC1=CC2=C(C=C1OC(=O)N3CCN(C)C[C@H]3C)C(NC4=CC=CC(Cl)=C4F)=NC=N2

InChI

MXDSJQHFFDGFDK-CYBMUJFWSA-N
InChI=1S/C22H23ClFN5O3/c1-13-11-28(2)7-8-29(13)22(30)32-19-9-14-17(10-18(19)31-3)25-12-26-21(14)27-16-6-4-5-15(23)20(16)24/h4-6,9-10,12-13H,7-8,11H2,1-3H3,(H,25,26,27)/t13-/m1/s1
Name Type Language Details References
ZORIFERTINIB
Domain Jurisdiction Naming Organization
drug  
INN  
Official Name
English  
AZD-3759
Common Name
English  
AZD3759
Code
English  
AZD 3759 [WHO-DD]
Common Name
English  
1-PIPERAZINECARBOXYLIC ACID, 2,4-DIMETHYL-, 4-((3-CHLORO-2-FLUOROPHENYL)AMINO)-7-METHOXY-6-QUINAZOLINYL ESTER, (2R)-
Systematic Name
English  
ZORIFERTINIB [INN]
Common Name
English  
Code System Code Type Description References
INN
11144
Created by admin on Thu Mar 26 02:24:25 EDT 2020 , Edited by admin on Thu Mar 26 02:24:25 EDT 2020
PRIMARY
PUBCHEM
78209992
Created by admin on Thu Mar 26 02:24:25 EDT 2020 , Edited by admin on Thu Mar 26 02:24:25 EDT 2020
PRIMARY
CAS
1626387-80-1
Created by admin on Thu Mar 26 02:24:25 EDT 2020 , Edited by admin on Thu Mar 26 02:24:25 EDT 2020
PRIMARY
Related Record Type Details References
TARGET -> INHIBITOR
Mediator Substance Details
none
IC50
Created by admin on Thu Mar 26 02:24:25 EDT 2020 , Edited by admin on Thu Mar 26 02:24:25 EDT 2020
TARGET -> INHIBITOR
Mediator Substance Details
none
IC50
Created by admin on Thu Mar 26 02:24:25 EDT 2020 , Edited by admin on Thu Mar 26 02:24:25 EDT 2020
SALT/SOLVATE -> PARENT
none
none
Mediator Substance Details
none
Created by admin on Thu Mar 26 02:24:25 EDT 2020 , Edited by admin on Thu Mar 26 02:24:25 EDT 2020
TARGET -> INHIBITOR
Mediator Substance Details
none
IC50
Created by admin on Thu Mar 26 02:24:25 EDT 2020 , Edited by admin on Thu Mar 26 02:24:25 EDT 2020
Related Record Type Details References
ACTIVE MOIETY
none
none
Mediator Substance Details
none
Created by admin on Thu Mar 26 02:24:25 EDT 2020 , Edited by admin on Thu Mar 26 02:24:25 EDT 2020
Name Property Type Amount Referenced Substance Defining Parameters References
CSF/PLASMA RATIO BIOLOGICAL SPECIES
BIOLOGICAL
Created Thu Mar 26 02:24:25 EDT 2020
Created By admin
Last Edited Thu Mar 26 02:24:25 EDT 2020
Last Edited By admin
Index Source Text / Citation Source Type Tags Date Accessed File
1 stn SRS NOMEN PUBLIC_DOMAIN_RELEASE AUTO_SELECTED
2 STN SRS NOMEN
3 INN 121 INN_LIST NOMEN PUBLIC_DOMAIN_RELEASE
4 dump-public-2020-03-25.gsrs BATCH_IMPORT Thu Mar 26 02:24:25 EDT 2020
5 SRS CODE IMPORT SRS NOMEN Fri Apr 28 15:26:51 EDT 2017
6 Journal of Medicinal Chemistry (2015), 58(20), 8200-8215 SRS NOMEN
7 STN (SCIFINDER) STN (SCIFINDER) NOMEN
8 Yang, Zhenfan, et al. "AZD3759, a BBB-penetrating EGFR inhibitor for the treatment of EGFR mutant NSCLC with CNS metastases." Science translational medicine 8.368 (2016): 368ra172-368ra172. JA PUBLIC_DOMAIN_RELEASE
9 STN STN (SCIFINDER)
10 WHO-DD WHO DRUG DICTIONARY
11 SRS import [67SX9H68W2] SRS NOMEN Fri Apr 28 15:26:51 EDT 2017

Molecular Formula C22H23ClFN5O3
Molecular Weight 459.901
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED