Basic Searches
Searches without any special characters (listed below) will return items that contain the exact value(s) entered in the search field. This means that searching for "ASPIRIN CALCIUM" won't return any items that have "ASPIRIN GLYCINE CALCIUM" because the search term doesn't match exactly.
Boolean Operators
OR - searches with terms separated by " OR " will return items that contain any of the terms in the search.
Example: "ASPIRIN" OR "CALCIUM" will return items that have strings like "ASPIRIN GLYCINE" and "GLYCINE CALCIUM" because they contain at least one of the terms in the search.

AND - searches with terms separated by " AND " will return items that contain all the terms in the search.
Example: "ASPIRIN" AND "CALCIUM" won't return items that have strings "ASPIRIN GLYCINE" and "GLYCINE CALCIUM" because neither contain both terms, but it will return "ASPIRIN GLYCINE CALCIUM" because it contains both search terms.
version 2.5
Substance Class Protein
Protein Type RECEPTOR
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
RO03J093CP
Record Status Validated (UNII)
Record Version
This is an older version of the record
Show Definitional References Hide Definitional References
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Name Type Language Details References
EPIDERMAL GROWTH FACTOR RECEPTOR
Common Name
English  
ERBB
Common Name
English  
RECEPTOR TYROSINE-PROTEIN KINASE ERBB-1
Common Name
English  
EGFR
Common Name
English  
HER1
Common Name
English  
HER-1
Common Name
English  
PROTO-ONCOGENE C-ERBB-1
Common Name
English  
Code System Code Type Description References
UNIPROT
P00533
Created by admin on Wed Mar 25 20:26:41 EDT 2020 , Edited by admin on Wed Mar 25 20:26:41 EDT 2020
PRIMARY
From To
1_7 1_34
1_133 1_163
1_166 1_175
1_170 1_183
1_191 1_199
1_195 1_207
1_208 1_216
1_212 1_224
1_227 1_236
1_240 1_267
1_271 1_283
1_287 1_302
1_305 1_309
1_313 1_338
1_446 1_475
1_482 1_491
1_486 1_499
1_502 1_511
1_515 1_531
1_534 1_547
1_538 1_555
1_558 1_567
1_571 1_593
1_596 1_604
1_600 1_612
Glycosylation Link Type Site
N 1_32
N 1_49
N 1_104
N 1_151
N 1_172
N 1_328
N 1_337
N 1_389
N 1_420
N 1_504
N 1_544
N 1_579
N 1_599
Related Record Type Details References
INHIBITOR -> TARGET
none
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:42 EDT 2020 , Edited by admin on Wed Mar 25 20:26:42 EDT 2020
RADIOLIGAND->TARGET
none
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:42 EDT 2020 , Edited by admin on Wed Mar 25 20:26:42 EDT 2020
INHIBITOR -> TARGET
Mediator Substance Details
none
INHIBITOR
IC50
Created by admin on Wed Mar 25 20:58:32 EDT 2020 , Edited by admin on Wed Mar 25 20:58:32 EDT 2020
INHIBITOR -> TARGET
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:41 EDT 2020 , Edited by admin on Wed Mar 25 20:26:41 EDT 2020
INHIBITOR -> TARGET
none
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:42 EDT 2020 , Edited by admin on Wed Mar 25 20:26:42 EDT 2020
INHIBITOR -> TARGET
none
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:41 EDT 2020 , Edited by admin on Wed Mar 25 20:26:41 EDT 2020
INHIBITOR -> TARGET
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:42 EDT 2020 , Edited by admin on Wed Mar 25 20:26:42 EDT 2020
INHIBITOR -> TARGET
none
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:42 EDT 2020 , Edited by admin on Wed Mar 25 20:26:42 EDT 2020
INHIBITOR -> TARGET
none
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:42 EDT 2020 , Edited by admin on Wed Mar 25 20:26:42 EDT 2020
INHIBITOR -> TARGET
none
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:41 EDT 2020 , Edited by admin on Wed Mar 25 20:26:41 EDT 2020
CONJUGATED TOXIN->TARGET
none
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:42 EDT 2020 , Edited by admin on Wed Mar 25 20:26:42 EDT 2020
INHIBITOR -> TARGET
none
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:41 EDT 2020 , Edited by admin on Wed Mar 25 20:26:41 EDT 2020
INHIBITOR -> TARGET
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 21:21:08 EDT 2020 , Edited by admin on Wed Mar 25 21:21:08 EDT 2020
INHIBITOR -> TARGET
none
Mediator Substance Details
none
IC50
Created by admin on Wed Mar 25 20:26:41 EDT 2020 , Edited by admin on Wed Mar 25 20:26:41 EDT 2020
CONJUGATED TOXIN->TARGET
none
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:41 EDT 2020 , Edited by admin on Wed Mar 25 20:26:41 EDT 2020
INHIBITOR -> TARGET
Mediator Substance Details
none
IRREVERSIBLE INHIBITOR
Created by admin on Wed Mar 25 20:26:41 EDT 2020 , Edited by admin on Wed Mar 25 20:26:41 EDT 2020
INHIBITOR -> TARGET
none
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:41 EDT 2020 , Edited by admin on Wed Mar 25 20:26:41 EDT 2020
INHIBITOR -> TARGET
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:42 EDT 2020 , Edited by admin on Wed Mar 25 20:26:42 EDT 2020
INHIBITOR -> TARGET
none
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:42 EDT 2020 , Edited by admin on Wed Mar 25 20:26:42 EDT 2020
INHIBITOR -> TARGET
none
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:42 EDT 2020 , Edited by admin on Wed Mar 25 20:26:42 EDT 2020
INHIBITOR -> TARGET
none
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:41 EDT 2020 , Edited by admin on Wed Mar 25 20:26:41 EDT 2020
INHIBITOR -> TARGET
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:41 EDT 2020 , Edited by admin on Wed Mar 25 20:26:41 EDT 2020
INHIBITOR -> TARGET
none
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:42 EDT 2020 , Edited by admin on Wed Mar 25 20:26:42 EDT 2020
INHIBITOR -> TARGET
Mediator Substance Details
none
IRREVERSIBLE INHIBITOR
Created by admin on Wed Mar 25 20:26:41 EDT 2020 , Edited by admin on Wed Mar 25 20:26:41 EDT 2020
INHIBITOR -> TARGET
Mediator Substance Details
none
IC50
Created by admin on Wed Mar 25 20:26:42 EDT 2020 , Edited by admin on Wed Mar 25 20:26:42 EDT 2020
INHIBITOR -> TARGET
none
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:42 EDT 2020 , Edited by admin on Wed Mar 25 20:26:42 EDT 2020
CONJUGATED TOXIN->TARGET
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:41 EDT 2020 , Edited by admin on Wed Mar 25 20:26:41 EDT 2020
INHIBITOR -> TARGET
none
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:41 EDT 2020 , Edited by admin on Wed Mar 25 20:26:41 EDT 2020
INHIBITOR -> TARGET
none
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:42 EDT 2020 , Edited by admin on Wed Mar 25 20:26:42 EDT 2020
INHIBITOR -> TARGET
none
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:41 EDT 2020 , Edited by admin on Wed Mar 25 20:26:41 EDT 2020
LIGAND->TARGET
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:42 EDT 2020 , Edited by admin on Wed Mar 25 20:26:42 EDT 2020
INHIBITOR -> TARGET
Mediator Substance Details
none
IC50
Created by admin on Wed Mar 25 20:26:42 EDT 2020 , Edited by admin on Wed Mar 25 20:26:42 EDT 2020
INHIBITOR -> TARGET
none
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:41 EDT 2020 , Edited by admin on Wed Mar 25 20:26:41 EDT 2020
INHIBITOR -> TARGET
none
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:41 EDT 2020 , Edited by admin on Wed Mar 25 20:26:41 EDT 2020
INHIBITOR -> TARGET
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:42 EDT 2020 , Edited by admin on Wed Mar 25 20:26:42 EDT 2020
INHIBITOR -> TARGET
none
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:41 EDT 2020 , Edited by admin on Wed Mar 25 20:26:41 EDT 2020
INHIBITOR -> TARGET
none
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:41 EDT 2020 , Edited by admin on Wed Mar 25 20:26:41 EDT 2020
INHIBITOR -> TARGET
none
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:41 EDT 2020 , Edited by admin on Wed Mar 25 20:26:41 EDT 2020
INHIBITOR -> TARGET
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:42 EDT 2020 , Edited by admin on Wed Mar 25 20:26:42 EDT 2020
INHIBITOR -> TARGET
none
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:41 EDT 2020 , Edited by admin on Wed Mar 25 20:26:41 EDT 2020
LIGAND->TARGET
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:42 EDT 2020 , Edited by admin on Wed Mar 25 20:26:42 EDT 2020
LIGAND->TARGET
none
none
Mediator Substance Details
none
Created by admin on Wed Mar 25 20:26:42 EDT 2020 , Edited by admin on Wed Mar 25 20:26:42 EDT 2020
Structural Modifications
Modification Type Location Site Location Type Residue Modified Extent Modification Name Modification ID
AMINO ACID SUBSTITUTION [1_974] [1_992] [1_1068] [1_1086] [1_1148] [1_1173] TYROSINE O-PHOSPHATE 2R86C98KDX
AMINO ACID SUBSTITUTION [1_654] THREONINE PHOSPHATE 3L4WX7B1EI
AMINO ACID SUBSTITUTION [1_1175] TILARGININE 27JT06E6GR
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL 0
Created Wed Mar 25 20:26:41 EDT 2020
Created By admin
Last Edited Wed Mar 25 20:26:41 EDT 2020
Last Edited By admin
Index Source Text / Citation Source Type Tags Date Accessed File
1 Park, W. , Han, S. , Lee, J. , Hong, T. , Won, J. , Lim, Y. , Lee, K. , Byun, H. Y. and Yim, D. (2017), Use of a Target?€?Mediated Drug Disposition Model to Predict the Human Pharmacokinetics and Target Occupancy of GC1118, an Anti?€?epidermal Growth Factor Receptor Antibody. Basic Clin Pharmacol Toxicol, 120: 243-249. doi:10.1111/bcpt.12675 JA
2 https://adisinsight.springer.com/drugs/800055959 WEB PAGE
3 http://www.uniprot.org/uniprot/P00533 SRS NOMEN PUBLIC_DOMAIN_RELEASE AUTO_SELECTED
4 CURRENT OPINION IN PHARMACOLOGY [1471-4892] CRESCENZO, RAMONA YR:2015 VOL:23 PG:39 -44 JOURNAL ARTICLE NOMEN
5 dump-public-2020-03-25.gsrs BATCH_IMPORT Wed Mar 25 20:26:41 EDT 2020
6 https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C150373 NCI THESAURUS PUBLIC_DOMAIN_RELEASE
7 https://ncit.nci.nih.gov/ncitbrowser/pages/home.jsf NCI THESAURUS PUBLIC_DOMAIN_RELEASE NOMEN
8 https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C150373 NCI THESAURUS PUBLIC_DOMAIN_RELEASE
9 Kim, Tae-Yong, et al. "A phase I/II study of poziotinib combined with paclitaxel and trastuzumab in patients with HER2-positive advanced gastric cancer." Gastric Cancer (2019): 1-9. JA CLIN NOMEN POT
10 Metabolism and Disposition of [14C]BMS-690514, an ErbB/Vascular Endothelial Growth Factor Receptor Inhibitor, after Oral Administration to Humans Lisa J. Christopher, Haizheng Hong, Blisse J. Vakkalagadda, Pamela L. Clemens, Hong Su, Vikram Roongta, Alban Allentoff, Haojun Sun, Kevin Heller, Christopher T. Harbison, Ramaswamy A. Iyer, William G. Humphreys, Tai Wong and Steven Zhang Drug Metabolism and Disposition November 2010, 38 (11) 2049-2059; DOI: https://doi.org/10.1124/dmd.110.034850 JA PUBLIC_DOMAIN_RELEASE
11 https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C99169 NCI THESAURUS NOMEN PUBLIC_DOMAIN_RELEASE
12 Generated from relationship on:'GEFITINIB' SYSTEM
13 SRS import [RO03J093CP] SRS NOMEN Fri Apr 28 11:32:26 EDT 2017
14 UNIPROT UNIPROT NOMEN
15 https://adisinsight.springer.com/drugs/800035283 WEB PAGE NOMEN
16 NCT04077255 CLINICAL_TRIALS.GOV
17 SRS CODE IMPORT SRS NOMEN Fri Apr 28 11:32:26 EDT 2017
18 Trends in Pharmacological Sciences, November 2014, Vol. 35, No. 11 604-620 WEBSITE NOMEN
19 http://dx.doi.org/10.1016/j.lungcan.2016.01.003 JOURNAL ARTICLE NOMEN
20 Generated from relationship on:'BRIGATINIB' SYSTEM
21 Metabolism and Disposition of [14C]BMS-690514, an ErbB/Vascular Endothelial Growth Factor Receptor Inhibitor, after Oral Administration to Humans Lisa J. Christopher, Haizheng Hong, Blisse J. Vakkalagadda, Pamela L. Clemens, Hong Su, Vikram Roongta, Alban Allentoff, Haojun Sun, Kevin Heller, Christopher T. Harbison, Ramaswamy A. Iyer, William G. Humphreys, Tai Wong and Steven Zhang Drug Metabolism and Disposition November 2010, 38 (11) 2049-2059; DOI: https://doi.org/10.1124/dmd.110.034850 JA PUBLIC_DOMAIN_RELEASE
22 https://en.wikipedia.org/wiki/Panitumumab SRS NOMEN
23 P122 INN PUBLIC_DOMAIN_RELEASE
24 https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C150373 NCI THESAURUS PUBLIC_DOMAIN_RELEASE
25 Metabolism and Disposition of [14C]BMS-690514, an ErbB/Vascular Endothelial Growth Factor Receptor Inhibitor, after Oral Administration to Humans Lisa J. Christopher, Haizheng Hong, Blisse J. Vakkalagadda, Pamela L. Clemens, Hong Su, Vikram Roongta, Alban Allentoff, Haojun Sun, Kevin Heller, Christopher T. Harbison, Ramaswamy A. Iyer, William G. Humphreys, Tai Wong and Steven Zhang Drug Metabolism and Disposition November 2010, 38 (11) 2049-2059; DOI: https://doi.org/10.1124/dmd.110.034850 JA PUBLIC_DOMAIN_RELEASE
26 https://adisinsight.springer.com/drugs/800035283 WEB PAGE NOMEN
27 https://www.selleckchem.com/products/theliatinib-hmpl-309.html WEB PAGE
28 https://adisinsight.springer.com/drugs/800042094 WEB PAGE
29 https://en.wikipedia.org/wiki/Panitumumab WEBSITE NOMEN
30 Metabolism and Disposition of [14C]BMS-690514, an ErbB/Vascular Endothelial Growth Factor Receptor Inhibitor, after Oral Administration to Humans Lisa J. Christopher, Haizheng Hong, Blisse J. Vakkalagadda, Pamela L. Clemens, Hong Su, Vikram Roongta, Alban Allentoff, Haojun Sun, Kevin Heller, Christopher T. Harbison, Ramaswamy A. Iyer, William G. Humphreys, Tai Wong and Steven Zhang Drug Metabolism and Disposition November 2010, 38 (11) 2049-2059; DOI: https://doi.org/10.1124/dmd.110.034850 JA PUBLIC_DOMAIN_RELEASE
31 https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C99169 NCI THESAURUS NOMEN PUBLIC_DOMAIN_RELEASE
32 https://www.adcreview.com/drugmap/losatuxizumab-vedotin-abbv-221/ WEB PAGE
33 Kim, Eunyoung, et al. "Metabolite identification of a new tyrosine kinase inhibitor, HM781?€?36B, and a pharmacokinetic study by liquid chromatography/tandem mass spectrometry." Rapid Communications in Mass Spectrometry 27.11 (2013): 1183-1195. JA NOMEN PUBLIC_DOMAIN_RELEASE
34 C.-S. TAN ET AL. / LUNG CANCER 93 (2016) 59?68 JOURNAL ARTICLE NOMEN
35 PUBCHEM NLM PUBLIC_DOMAIN_RELEASE NOMEN

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88
admin
Thu Mar 26 02:23:20 EDT 2020
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Wed Mar 25 23:23:39 EDT 2020
86
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Wed Mar 25 23:05:58 EDT 2020
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Wed Mar 25 22:42:11 EDT 2020
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Wed Mar 25 22:34:53 EDT 2020
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Wed Mar 25 21:21:07 EDT 2020
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