Basic Searches
Searches without any special characters (listed below) will return items that contain the exact value(s) entered in the search field. This means that searching for "ASPIRIN CALCIUM" won't return any items that have "ASPIRIN GLYCINE CALCIUM" because the search term doesn't match exactly.
Boolean Operators
OR - searches with terms separated by " OR " will return items that contain any of the terms in the search.
Example: "ASPIRIN" OR "CALCIUM" will return items that have strings like "ASPIRIN GLYCINE" and "GLYCINE CALCIUM" because they contain at least one of the terms in the search.

AND - searches with terms separated by " AND " will return items that contain all the terms in the search.
Example: "ASPIRIN" AND "CALCIUM" won't return items that have strings "ASPIRIN GLYCINE" and "GLYCINE CALCIUM" because neither contain both terms, but it will return "ASPIRIN GLYCINE CALCIUM" because it contains both search terms.
version 2.5
Substance Class Chemical
Record UNII
41UD74L59M
Record Status Validated (UNII)
Record Version
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Details

Stereochemistry ABSOLUTE
Molecular Formula C24H25ClFN5O3
Molecular Weight 485.938
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 1
Charge 0
Created by admin on Thu Mar 26 01:06:16 EDT 2020
Edited by admin on Thu Mar 26 01:06:16 EDT 2020
Structure of AFATINIB

Systematic Names:

  • None recorded
  • {{name}}

SMILES

CN(C)C\C=C\C(=O)NC1=CC2=C(C=C1O[C@H]3CCOC3)N=CN=C2NC4=CC(Cl)=C(F)C=C4

InChI

ULXXDDBFHOBEHA-CWDCEQMOSA-N
InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1
Name Type Language Details References
AFATINIB
Domain Jurisdiction Naming Organization
drug  
INN   USAN  
DASH   INN   MART.   MI   USAN   VANDF   WHO-DD  
Official Name
English  
AFATINIB [WHO-DD]
Common Name
English  
AFATINIB [MI]
Common Name
English  
TOVOK
Brand Name
English  
AFATINIB [USAN]
Common Name
English  
BIBW 2992
Common Name
English  
AFATINIB [VANDF]
Common Name
English  
(2E)-N-(4-(3-CHLORO-4-FLUOROANILINO)-7-(((3S)-OXOLAN-3-YL)OXY)QUINOXAZOLIN-6-YL)-4-(DIMETHYLAMINO)BUT-2-ENAMIDE
Common Name
English  
TOMTOVOK
Brand Name
English  
BIBW2992
Code
English  
AFATINIB [INN]
Common Name
English  
BIBW-2992
Code
English  
AFATINIB [MART.]
Common Name
English  
2-BUTENAMIDE, N-(4-((3-CHLORO-4-FLUOROPHENYL)AMINO)-7-(((3S)-TETRAHYDRO-3-FURANYL)OXY)- 6-QUINAZOLINYL)-4-(DIMETHYLAMINO)-, (2E)-
Common Name
English  
Classification Tree Code System Code References
NDF-RT N0000175605
Created by admin on Thu Mar 26 01:06:16 EDT 2020 , Edited by admin on Thu Mar 26 01:06:16 EDT 2020
WHO-VATC QL01XE13
Created by admin on Thu Mar 26 01:06:16 EDT 2020 , Edited by admin on Thu Mar 26 01:06:16 EDT 2020
WHO-ATC L01XE13
Created by admin on Thu Mar 26 01:06:16 EDT 2020 , Edited by admin on Thu Mar 26 01:06:16 EDT 2020
FDA ORPHAN DRUG 484115
Created by admin on Thu Mar 26 01:06:16 EDT 2020 , Edited by admin on Thu Mar 26 01:06:16 EDT 2020
NCI_THESAURUS C2167
Created by admin on Thu Mar 26 01:06:16 EDT 2020 , Edited by admin on Thu Mar 26 01:06:16 EDT 2020
EU-Orphan Drug EU/3/18/2110
Created by admin on Thu Mar 26 01:06:16 EDT 2020 , Edited by admin on Thu Mar 26 01:06:16 EDT 2020
EMA ASSESSMENT REPORTS GIOTRIF(AUTHORIZED: CARCINOMA, NON-SMALL-CELL LUNG)
Created by admin on Thu Mar 26 01:06:16 EDT 2020 , Edited by admin on Thu Mar 26 01:06:16 EDT 2020
FDA ORPHAN DRUG 375712
Created by admin on Thu Mar 26 01:06:16 EDT 2020 , Edited by admin on Thu Mar 26 01:06:16 EDT 2020
FDA ORPHAN DRUG 433414
Created by admin on Thu Mar 26 01:06:16 EDT 2020 , Edited by admin on Thu Mar 26 01:06:16 EDT 2020
NCI_THESAURUS C129825
Created by admin on Thu Mar 26 01:06:16 EDT 2020 , Edited by admin on Thu Mar 26 01:06:16 EDT 2020
Code System Code Type Description References
CAS
439081-18-2
Created by admin on Thu Mar 26 01:06:16 EDT 2020 , Edited by admin on Thu Mar 26 01:06:16 EDT 2020
NON-SPECIFIC STEREOCHEMISTRY
WIKIPEDIA
AFATINIB
Created by admin on Thu Mar 26 01:06:16 EDT 2020 , Edited by admin on Thu Mar 26 01:06:16 EDT 2020
PRIMARY
PUBCHEM
10184653
Created by admin on Thu Mar 26 01:06:16 EDT 2020 , Edited by admin on Thu Mar 26 01:06:16 EDT 2020
PRIMARY
DRUG BANK
DB08916
Created by admin on Thu Mar 26 01:06:16 EDT 2020 , Edited by admin on Thu Mar 26 01:06:16 EDT 2020
PRIMARY
LactMed
850140-72-6
Created by admin on Thu Mar 26 01:06:16 EDT 2020 , Edited by admin on Thu Mar 26 01:06:16 EDT 2020
PRIMARY
NCI_THESAURUS
C66940
Created by admin on Thu Mar 26 01:06:16 EDT 2020 , Edited by admin on Thu Mar 26 01:06:16 EDT 2020
PRIMARY
ChEMBL
CHEMBL1173655
Created by admin on Thu Mar 26 01:06:16 EDT 2020 , Edited by admin on Thu Mar 26 01:06:16 EDT 2020
PRIMARY
MERCK INDEX
M1439
Created by admin on Thu Mar 26 01:06:16 EDT 2020 , Edited by admin on Thu Mar 26 01:06:16 EDT 2020
PRIMARY Merck Index
CAS
850140-72-6
Created by admin on Thu Mar 26 01:06:16 EDT 2020 , Edited by admin on Thu Mar 26 01:06:16 EDT 2020
PRIMARY
RXCUI
1430438
Created by admin on Thu Mar 26 01:06:16 EDT 2020 , Edited by admin on Thu Mar 26 01:06:16 EDT 2020
PRIMARY RxNorm
INN
9230
Created by admin on Thu Mar 26 01:06:16 EDT 2020 , Edited by admin on Thu Mar 26 01:06:16 EDT 2020
PRIMARY
EVMPD
SUB32268
Created by admin on Thu Mar 26 01:06:16 EDT 2020 , Edited by admin on Thu Mar 26 01:06:16 EDT 2020
PRIMARY
IUPHAR
5667
Created by admin on Thu Mar 26 01:06:16 EDT 2020 , Edited by admin on Thu Mar 26 01:06:16 EDT 2020
PRIMARY
Related Record Type Details References
TARGET -> INHIBITOR
Mediator Substance Details
none
IRREVERSIBLE INHIBITOR
Created by admin on Thu Mar 26 01:06:25 EDT 2020 , Edited by admin on Thu Mar 26 01:06:25 EDT 2020
TARGET -> INHIBITOR
Mediator Substance Details
none
IRREVERSIBLE INHIBITOR
Created by admin on Thu Mar 26 01:06:25 EDT 2020 , Edited by admin on Thu Mar 26 01:06:25 EDT 2020
BINDER->LIGAND
Mediator Substance Details
none
BINDING
Created by admin on Thu Mar 26 01:06:16 EDT 2020 , Edited by admin on Thu Mar 26 01:06:16 EDT 2020
TARGET -> INHIBITOR
Mediator Substance Details
none
IRREVERSIBLE INHIBITOR
Created by admin on Thu Mar 26 01:06:25 EDT 2020 , Edited by admin on Thu Mar 26 01:06:25 EDT 2020
SALT/SOLVATE -> PARENT
none
none
Mediator Substance Details
none
Created by admin on Thu Mar 26 01:06:16 EDT 2020 , Edited by admin on Thu Mar 26 01:06:16 EDT 2020
Related Record Type Details References
METABOLITE -> PARENT
Mediator Substance Details
none
MINOR
minor metabolite
URINE
Created by admin on Thu Mar 26 01:06:16 EDT 2020 , Edited by admin on Thu Mar 26 01:06:16 EDT 2020
METABOLITE LESS ACTIVE -> PARENT
none
Mediator Substance Details
Created by admin on Thu Mar 26 01:06:16 EDT 2020 , Edited by admin on Thu Mar 26 01:06:16 EDT 2020
METABOLITE -> PARENT
none
none
Mediator Substance Details
none
Created by admin on Thu Mar 26 01:06:16 EDT 2020 , Edited by admin on Thu Mar 26 01:06:16 EDT 2020
Related Record Type Details References
ACTIVE MOIETY
none
none
Mediator Substance Details
none
Created by admin on Thu Mar 26 01:06:16 EDT 2020 , Edited by admin on Thu Mar 26 01:06:16 EDT 2020
Name Property Type Amount Referenced Substance Defining Parameters References
Biological Half-life PHARMACOKINETIC
Cmax PHARMACOKINETIC
Volume of Distribution PHARMACOKINETIC
Note References
[Validation]WARNING:Code 'N0000175605'[NDF-RT] collides (possible duplicate) with existing code & codeSystem for substance:
[I42748ELQW]ACALABRUTINIB
Created Thu Mar 26 01:06:16 EDT 2020
Created By admin
Last Edited Thu Mar 26 01:06:16 EDT 2020
Last Edited By admin
Index Source Text / Citation Source Type Tags Date Accessed File
1 https://www.ncbi.nlm.nih.gov/pubmed/22200729 NCBI
2 AFATINIB [DASH] SRS_LOCATOR
3 WHO-DD SRS NOMEN
4 SRS CODE IMPORT SRS NOMEN Fri Apr 28 14:47:26 EDT 2017
5 GSRS System-generated Validation messages VALIDATION_MESSAGE Thu Mar 26 01:06:15 EDT 2020
6 AFATINIB [VANDF] SRS_LOCATOR
7 https://www.clinicalkey.com/pharmacology/monograph/3820?sec=monphar BOOK
8 USAN COUN 2011 SRS NOMEN
9 http://dx.doi.org/10.1016/j.lungcan.2016.01.003 JOURNAL ARTICLE NOMEN
10 USAN COUN 2010 USANCOUN NOMEN PUBLIC_DOMAIN_RELEASE
11 MI MERCK INDEX PUBLIC_DOMAIN_RELEASE NOMEN
12 INN INN NOMEN
13 USP DICTIONARY 2010 SRS NOMEN
14 NDF-RT SRS NOMEN
15 AFATINIB [WHO-DD] SRS_LOCATOR
16 Generated from relationship on:'EPIDERMAL GROWTH FACTOR RECEPTOR' SYSTEM
17 AFATINIB [USAN] SRS_LOCATOR
18 http://fco.factsandcomparisons.com/lco/action/doc/retrieve/docid/fc_dfc/5550383#f_pharmacokinetics LEPINDEX
19 WEBSITE WEBSITE NOMEN PUBLIC_DOMAIN_RELEASE
20 AFATINIB [MART.] SRS_LOCATOR
21 FDA_SRS SRS NOMEN
22 STN STN (SCIFINDER)
23 MERCK SRS NOMEN
24 INN 2010 SRS NOMEN
25 inn list 102 SRS NOMEN
26 http://www.accessdata.fda.gov/drugsatfda_docs/nda/2013/201292Orig1s000ClinPharmR.pdf NDA PUBLIC REVIEW NOMEN
27 SRS import [41UD74L59M] SRS NOMEN Fri Apr 28 14:47:26 EDT 2017
28 SYSTEM
29 GSRS System-generated Validation messages VALIDATION_MESSAGE Thu Mar 26 01:06:15 EDT 2020
30 MARTINDALE 2011 SRS NOMEN
31 USP DICTIONARY 2012 SRS NOMEN
32 usan coun SRS NOMEN
33 STN STN (SCIFINDER)
34 INN SRS NOMEN PUBLIC_DOMAIN_RELEASE AUTO_SELECTED
35 AFATINIB [INN] SRS_LOCATOR
36 AFATINIB [MI] SRS_LOCATOR
37 STN SRS NOMEN

Molecular Formula C24H25ClFN5O3
Molecular Weight 485.938
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry
Defined Stereocenters 1 / 1
E/Z Centers 1
Optical Activity UNSPECIFIED