Basic Searches
Searches without any special characters (listed below) will return items that contain the exact value(s) entered in the search field. This means that searching for "ASPIRIN CALCIUM" won't return any items that have "ASPIRIN GLYCINE CALCIUM" because the search term doesn't match exactly.
Boolean Operators
OR - searches with terms separated by " OR " will return items that contain any of the terms in the search.
Example: "ASPIRIN" OR "CALCIUM" will return items that have strings like "ASPIRIN GLYCINE" and "GLYCINE CALCIUM" because they contain at least one of the terms in the search.

AND - searches with terms separated by " AND " will return items that contain all the terms in the search.
Example: "ASPIRIN" AND "CALCIUM" won't return items that have strings "ASPIRIN GLYCINE" and "GLYCINE CALCIUM" because neither contain both terms, but it will return "ASPIRIN GLYCINE CALCIUM" because it contains both search terms.
version 2.5
Substance Class Chemical
Record UNII
0VUA21238F
Record Status Validated (UNII)
Record Version
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Details

Stereochemistry ACHIRAL
Molecular Formula C29H26ClFN4O4S
Molecular Weight 581.058
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0
Created by admin on Thu Mar 26 02:42:10 EDT 2020
Edited by admin on Thu Mar 26 02:42:10 EDT 2020
Structure of LAPATINIB

Systematic Names:

  • None recorded
  • {{name}}

SMILES

CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC=C3N=CN=C(NC4=CC=C(OCC5=CC=CC(F)=C5)C(Cl)=C4)C3=C2

InChI

BCFGMOOMADDAQU-UHFFFAOYSA-N
InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35)
Name Type Language Details References
LAPATINIB
Domain Jurisdiction Naming Organization
drug  
INN  
EMA EPAR   INN   MI   VANDF   WHO-DD  
Official Name
English  
LAPATINIB [EMA EPAR]
Common Name
English  
LAPATINIB [INN]
Common Name
English  
GSK-572016
Code
English  
GW-572016X
Code
English  
LAPATINIB [MI]
Common Name
English  
LAPATINIB [WHO-DD]
Common Name
English  
GW572016
Code
English  
LAPATINIB [VANDF]
Common Name
English  
GW-572016
Code
English  
Classification Tree Code System Code References
NDF-RT N0000175605
Created by admin on Thu Mar 26 02:42:10 EDT 2020 , Edited by admin on Thu Mar 26 02:42:10 EDT 2020
NDF-RT N0000175076
Created by admin on Thu Mar 26 02:42:10 EDT 2020 , Edited by admin on Thu Mar 26 02:42:10 EDT 2020
WHO-VATC QL01XE07
Created by admin on Thu Mar 26 02:42:10 EDT 2020 , Edited by admin on Thu Mar 26 02:42:10 EDT 2020
NCI_THESAURUS C155764
Created by admin on Thu Mar 26 02:42:10 EDT 2020 , Edited by admin on Thu Mar 26 02:42:10 EDT 2020
LIVERTOX 542
Created by admin on Thu Mar 26 02:42:10 EDT 2020 , Edited by admin on Thu Mar 26 02:42:10 EDT 2020
NCI_THESAURUS C2167
Created by admin on Thu Mar 26 02:42:10 EDT 2020 , Edited by admin on Thu Mar 26 02:42:10 EDT 2020
NCI_THESAURUS C129825
Created by admin on Thu Mar 26 02:42:10 EDT 2020 , Edited by admin on Thu Mar 26 02:42:10 EDT 2020
FDA ORPHAN DRUG 284209
Created by admin on Thu Mar 26 02:42:10 EDT 2020 , Edited by admin on Thu Mar 26 02:42:10 EDT 2020
WHO-ATC L01XE07
Created by admin on Thu Mar 26 02:42:10 EDT 2020 , Edited by admin on Thu Mar 26 02:42:10 EDT 2020
Code System Code Type Description References
ChEMBL
CHEMBL554
Created by admin on Thu Mar 26 02:42:10 EDT 2020 , Edited by admin on Thu Mar 26 02:42:10 EDT 2020
PRIMARY
RXCUI
480167
Created by admin on Thu Mar 26 02:42:10 EDT 2020 , Edited by admin on Thu Mar 26 02:42:10 EDT 2020
PRIMARY RxNorm
MESH
C490728
Created by admin on Thu Mar 26 02:42:10 EDT 2020 , Edited by admin on Thu Mar 26 02:42:10 EDT 2020
PRIMARY
LactMed
231277-92-2
Created by admin on Thu Mar 26 02:42:10 EDT 2020 , Edited by admin on Thu Mar 26 02:42:10 EDT 2020
PRIMARY
PUBCHEM
208908
Created by admin on Thu Mar 26 02:42:10 EDT 2020 , Edited by admin on Thu Mar 26 02:42:10 EDT 2020
PRIMARY
NCI_THESAURUS
C26653
Created by admin on Thu Mar 26 02:42:10 EDT 2020 , Edited by admin on Thu Mar 26 02:42:10 EDT 2020
PRIMARY
EVMPD
SUB25379
Created by admin on Thu Mar 26 02:42:10 EDT 2020 , Edited by admin on Thu Mar 26 02:42:10 EDT 2020
PRIMARY
IUPHAR
5692
Created by admin on Thu Mar 26 02:42:10 EDT 2020 , Edited by admin on Thu Mar 26 02:42:10 EDT 2020
PRIMARY
HSDB
231277-92-2
Created by admin on Thu Mar 26 02:42:10 EDT 2020 , Edited by admin on Thu Mar 26 02:42:10 EDT 2020
PRIMARY
EPA CompTox
231277-92-2
Created by admin on Thu Mar 26 02:42:10 EDT 2020 , Edited by admin on Thu Mar 26 02:42:10 EDT 2020
PRIMARY
MERCK INDEX
M6688
Created by admin on Thu Mar 26 02:42:10 EDT 2020 , Edited by admin on Thu Mar 26 02:42:10 EDT 2020
PRIMARY Merck Index
INN
8378
Created by admin on Thu Mar 26 02:42:10 EDT 2020 , Edited by admin on Thu Mar 26 02:42:10 EDT 2020
PRIMARY
WIKIPEDIA
LAPATINIB
Created by admin on Thu Mar 26 02:42:10 EDT 2020 , Edited by admin on Thu Mar 26 02:42:10 EDT 2020
PRIMARY
CAS
231277-92-2
Created by admin on Thu Mar 26 02:42:10 EDT 2020 , Edited by admin on Thu Mar 26 02:42:10 EDT 2020
PRIMARY
Related Record Type Details References
TRANSPORTER -> INHIBITOR
Mediator Substance Details
none
Created by admin on Thu Mar 26 02:42:12 EDT 2020 , Edited by admin on Thu Mar 26 02:42:12 EDT 2020
BINDER->LIGAND
Mediator Substance Details
none
BINDING
Created by admin on Thu Mar 26 02:42:11 EDT 2020 , Edited by admin on Thu Mar 26 02:42:11 EDT 2020
TARGET -> INHIBITOR
none
Mediator Substance Details
none
Created by admin on Thu Mar 26 02:42:10 EDT 2020 , Edited by admin on Thu Mar 26 02:42:10 EDT 2020
TRANSPORTER -> SUBSTRATE
none
Mediator Substance Details
none
Created by admin on Thu Mar 26 02:42:13 EDT 2020 , Edited by admin on Thu Mar 26 02:42:13 EDT 2020
SALT/SOLVATE -> PARENT
none
none
Mediator Substance Details
none
Created by admin on Thu Mar 26 02:42:10 EDT 2020 , Edited by admin on Thu Mar 26 02:42:10 EDT 2020
EXCRETED UNCHANGED
Mediator Substance Details
none
AMOUNT EXCRETED
FECAL
Created by admin on Thu Mar 26 02:42:12 EDT 2020 , Edited by admin on Thu Mar 26 02:42:12 EDT 2020
Related Record Type Details References
ACTIVE MOIETY
none
none
Mediator Substance Details
none
Created by admin on Thu Mar 26 02:42:10 EDT 2020 , Edited by admin on Thu Mar 26 02:42:10 EDT 2020
Name Property Type Amount Referenced Substance Defining Parameters References
Tmax PHARMACOKINETIC ORAL ADMINISTRATION

Biological Half-life PHARMACOKINETIC
Note References
[Validation]WARNING:Code 'N0000175605'[NDF-RT] collides (possible duplicate) with existing code & codeSystem for substance:
[I42748ELQW]ACALABRUTINIB
[Validation]WARNING:Code 'N0000175076'[NDF-RT] collides (possible duplicate) with existing code & codeSystem for substance:
[624KN6GM2T]TEMSIROLIMUS
Created Thu Mar 26 02:42:10 EDT 2020
Created By admin
Last Edited Thu Mar 26 02:42:10 EDT 2020
Last Edited By admin
Index Source Text / Citation Source Type Tags Date Accessed File
1 Human Metabolism of Lapatinib, a Dual Kinase Inhibitor: Implications for Hepatotoxicity Stephen Castellino, Michael O'Mara, Kevin Koch, David J. Borts, Gary D. Bowers and Christopher MacLauchlin Drug Metabolism and Disposition January 2012, 40 (1) 139-150; DOI: https://doi.org/10.1124/dmd.111.040949 JA PUBLIC_DOMAIN_RELEASE
2 LAPATINIB [INN] SRS_LOCATOR
3 STN SRS NOMEN PUBLIC_DOMAIN_RELEASE AUTO_SELECTED
4 SRS import [0VUA21238F] SRS NOMEN Fri Apr 28 14:44:54 EDT 2017
5 MERCK INDEX MERCK INDEX NOMEN
6 SYSTEM
7 MERCK INDEX SRS NOMEN
8 Human Metabolism of Lapatinib, a Dual Kinase Inhibitor: Implications for Hepatotoxicity Stephen Castellino, Michael O'Mara, Kevin Koch, David J. Borts, Gary D. Bowers and Christopher MacLauchlin Drug Metabolism and Disposition January 2012, 40 (1) 139-150; DOI: https://doi.org/10.1124/dmd.111.040949 JA PUBLIC_DOMAIN_RELEASE
9 FDA_SRS SRS NOMEN
10 Human Metabolism of Lapatinib, a Dual Kinase Inhibitor: Implications for Hepatotoxicity Stephen Castellino, Michael O'Mara, Kevin Koch, David J. Borts, Gary D. Bowers and Christopher MacLauchlin Drug Metabolism and Disposition January 2012, 40 (1) 139-150; DOI: https://doi.org/10.1124/dmd.111.040949 JA PUBLIC_DOMAIN_RELEASE
11 Human Metabolism of Lapatinib, a Dual Kinase Inhibitor: Implications for Hepatotoxicity Stephen Castellino, Michael O'Mara, Kevin Koch, David J. Borts, Gary D. Bowers and Christopher MacLauchlin Drug Metabolism and Disposition January 2012, 40 (1) 139-150; DOI: https://doi.org/10.1124/dmd.111.040949 JA PUBLIC_DOMAIN_RELEASE
12 NDF-RT SRS NOMEN
13 Trends in Pharmacological Sciences, November 2014, Vol. 35, No. 11 604-620 WEBSITE NOMEN
14 LAPATINIB [EMA EPAR] SRS_LOCATOR
15 INN 2010 SRS NOMEN
16 WEBSITE WEBSITE NOMEN PUBLIC_DOMAIN_RELEASE
17 https://www.accessdata.fda.gov/drugsatfda_docs/nda/2007/022059s000_ClinPharmR.pdf NDA PUBLIC REVIEW PUBLIC_DOMAIN_RELEASE
18 Human Metabolism of Lapatinib, a Dual Kinase Inhibitor: Implications for Hepatotoxicity Stephen Castellino, Michael O'Mara, Kevin Koch, David J. Borts, Gary D. Bowers and Christopher MacLauchlin Drug Metabolism and Disposition January 2012, 40 (1) 139-150; DOI: https://doi.org/10.1124/dmd.111.040949 JA PUBLIC_DOMAIN_RELEASE
19 http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM292362.pdf FDA GUIDANCE NOMEN
20 SRS CODE IMPORT SRS NOMEN Fri Apr 28 14:44:54 EDT 2017
21 WEBSITE WEBSITE NOMEN PUBLIC_DOMAIN_RELEASE
22 LAPATINIB [WHO-DD] SRS_LOCATOR
23 LAPATINIB [VANDF] SRS_LOCATOR
24 GSRS System-generated Validation messages VALIDATION_MESSAGE Thu Mar 26 02:42:10 EDT 2020
25 https://www.clinicalkey.com/pharmacology/monograph/3562?sec=monphar LEPINDEX
26 Generated from relationship on:'MULTIDRUG RESISTANCE PROTEIN 1' SYSTEM
27 MOLECULAR PHARMACOLOGY OCTOBER 2010 VOL. 78 NO. 4 693-703 JOURNAL ARTICLE NOMEN
28 LAPATINIB [MI] SRS_LOCATOR
29 Generated from relationship on:'MULTIDRUG RESISTANCE PROTEIN 1' SYSTEM
30 Human Metabolism of Lapatinib, a Dual Kinase Inhibitor: Implications for Hepatotoxicity Stephen Castellino, Michael O'Mara, Kevin Koch, David J. Borts, Gary D. Bowers and Christopher MacLauchlin Drug Metabolism and Disposition January 2012, 40 (1) 139-150; DOI: https://doi.org/10.1124/dmd.111.040949 JA PUBLIC_DOMAIN_RELEASE
31 WEBSITE WEBSITE NOMEN PUBLIC_DOMAIN_RELEASE
32 WHO-DD SRS NOMEN
33 KATHAWALA, R.J., ET AL., THE MODULATION OF ABC TRANSPORTER-MEDIATED MULTIDRUG RESISTANCE IN CANCER: A REVIEW OF THE PAST DECADE. DRUG RESIST. UPDAT. (2014), HTTP://DX.DOI.ORG/10.1016/J.DRUP.2014.11.002 CAS NOMEN
34 Human Metabolism of Lapatinib, a Dual Kinase Inhibitor: Implications for Hepatotoxicity Stephen Castellino, Michael O'Mara, Kevin Koch, David J. Borts, Gary D. Bowers and Christopher MacLauchlin Drug Metabolism and Disposition January 2012, 40 (1) 139-150; DOI: https://doi.org/10.1124/dmd.111.040949 JA PUBLIC_DOMAIN_RELEASE
35 EMA SRS NOMEN
36 USP Dictionary 2007 SRS NOMEN
37 Human Metabolism of Lapatinib, a Dual Kinase Inhibitor: Implications for Hepatotoxicity Stephen Castellino, Michael O'Mara, Kevin Koch, David J. Borts, Gary D. Bowers and Christopher MacLauchlin Drug Metabolism and Disposition January 2012, 40 (1) 139-150; DOI: https://doi.org/10.1124/dmd.111.040949 JA PUBLIC_DOMAIN_RELEASE
38 Human Metabolism of Lapatinib, a Dual Kinase Inhibitor: Implications for Hepatotoxicity Stephen Castellino, Michael O'Mara, Kevin Koch, David J. Borts, Gary D. Bowers and Christopher MacLauchlin Drug Metabolism and Disposition January 2012, 40 (1) 139-150; DOI: https://doi.org/10.1124/dmd.111.040949 JA PUBLIC_DOMAIN_RELEASE
39 Human Metabolism of Lapatinib, a Dual Kinase Inhibitor: Implications for Hepatotoxicity Stephen Castellino, Michael O'Mara, Kevin Koch, David J. Borts, Gary D. Bowers and Christopher MacLauchlin Drug Metabolism and Disposition January 2012, 40 (1) 139-150; DOI: https://doi.org/10.1124/dmd.111.040949 JA PUBLIC_DOMAIN_RELEASE
40 STN STN (SCIFINDER)
41 Human Metabolism of Lapatinib, a Dual Kinase Inhibitor: Implications for Hepatotoxicity Stephen Castellino, Michael O'Mara, Kevin Koch, David J. Borts, Gary D. Bowers and Christopher MacLauchlin Drug Metabolism and Disposition January 2012, 40 (1) 139-150; DOI: https://doi.org/10.1124/dmd.111.040949 JA PUBLIC_DOMAIN_RELEASE
42 GSRS System-generated Validation messages VALIDATION_MESSAGE Thu Mar 26 02:42:10 EDT 2020

Molecular Formula C29H26ClFN4O4S
Molecular Weight 581.058
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE